Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study

Q. Song, R. Risco, M. Latina, F. Berthiaume, Y. Nahmias, M. L. Yarmush

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

Original languageAmerican English
Pages (from-to)10518-10528
Number of pages11
JournalOptics Express
Volume16
Issue number14
DOIs
StatePublished - 7 Jul 2008
Externally publishedYes

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