Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study

Q. Song; R. Risco; M. Latina; F. Berthiaume; Y. Nahmias; M. L. Yarmush

doi:10.1364/OE.16.010518

Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study

Q. Song, R. Risco, M. Latina, F. Berthiaume, Y. Nahmias, M. L. Yarmush

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm²; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

Original language	English
Pages (from-to)	10518-10528
Number of pages	11
Journal	Optics Express
Volume	16
Issue number	14
DOIs	https://doi.org/10.1364/OE.16.010518
State	Published - 7 Jul 2008
Externally published	Yes

Access to Document

10.1364/OE.16.010518

Cite this

@article{a06b01e318bd4453ab9910c6029e081a,

title = "Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study",

abstract = "This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.",

author = "Q. Song and R. Risco and M. Latina and F. Berthiaume and Y. Nahmias and Yarmush, {M. L.}",

year = "2008",

month = jul,

day = "7",

doi = "10.1364/OE.16.010518",

language = "אנגלית",

volume = "16",

pages = "10518--10528",

journal = "Optics Express",

issn = "1094-4087",

publisher = "Optica Publishing Group",

number = "14",

}

TY - JOUR

T1 - Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation

T2 - An in vitro study

AU - Song, Q.

AU - Risco, R.

AU - Latina, M.

AU - Berthiaume, F.

AU - Nahmias, Y.

AU - Yarmush, M. L.

PY - 2008/7/7

Y1 - 2008/7/7

N2 - This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

AB - This work describes the selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation. We observed: (1) single pulsed laser irradiation caused cellular damages on pigmented, and not on non-pigmented RPE cells at laser radiant exposure up to 2550 mJ/cm2; (2) in the mixture of pigmented and non-pigmented RPE cells, single pulsed laser-induced damage was confined to pigmented RPE cells. This study demonstrates that the pigmented RPE cells can be selectively damaged, using a single pulsed laser irradiation, without thermal coagulation to adjacent non-pigmented RPE cells.

UR - http://www.scopus.com/inward/record.url?scp=47249097946&partnerID=8YFLogxK

U2 - 10.1364/OE.16.010518

DO - 10.1364/OE.16.010518

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 18607465

AN - SCOPUS:47249097946

SN - 1094-4087

VL - 16

SP - 10518

EP - 10528

JO - Optics Express

JF - Optics Express

IS - 14

ER -

Selective targeting of pigmented retinal pigment epithelial (RPE) cells by a single pulsed laser irradiation: An in vitro study

Abstract

Access to Document

Other files and links

Fingerprint

Cite this