Selectivity in metal-catalyzed carbon-carbon bond cleavage of alkylidenecyclopropanes

Ahmad Masarwa, Ilan Marek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

181 Scopus citations

Abstract

When more complex system leads to simpler reactivity profile; the ring-opening of strained threemembered rings such as methylene- and alkylidenecyclopropanes generally lead to several products. If one starts with more functionalized carbon skeletons, selective reactions are now observed and rationalization as well as synthetic applications are described in this concept article. This methodology could be used to the preparation of challenging structural motifs possessing quaternary carbon stereocenters in acyclic systems.

Original languageAmerican English
Pages (from-to)9712-9721
Number of pages10
JournalChemistry - A European Journal
Volume16
Issue number32
DOIs
StatePublished - 23 Aug 2010
Externally publishedYes

Keywords

  • Alkylidenecyclopropane
  • Insertion
  • Quaternary stereocenters
  • Ring-opening
  • Selectivity

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