Selenium and Selenocysteine in Protein Chemistry

Reem Mousa, Rebecca Notis Dardashti, Norman Metanis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

123 Scopus citations


Selenocysteine, the selenium-containing analogue of cysteine, is the twenty-first proteinogenic amino acid. Since its discovery almost fifty years ago, it has been exploited in unnatural systems even more often than in natural systems. Selenocysteine chemistry has attracted the attention of many chemists in the field of chemical biology owing to its high reactivity and resulting potential for various applications such as chemical modification, chemical protein (semi)synthesis, and protein folding, to name a few. In this Minireview, we will focus on the chemistry of selenium and selenocysteine and their utility in protein chemistry.

Original languageAmerican English
Pages (from-to)15818-15827
Number of pages10
JournalAngewandte Chemie - International Edition
Issue number50
StatePublished - 11 Dec 2017

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • chemical protein synthesis
  • native chemical ligation
  • protein chemistry
  • selenocysteine
  • selenoproteins


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