Sensing phosphate across the kingdoms

Justin Silver*, Michal Dranitzki-Elhalel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Purpose of review: The present review summarizes recent findings that may help in understanding how the cell senses changes in serum phosphate. Recent findings: The sensing of phosphate determines the organism's response to change in supply of this essential nutrient. Phosphate depletion or surfeit results in homeostatic responses that involve changes in transcription, transcript stability, transporter recruitment or breakdown, and cell replication. These responses are shared across the biological kingdoms, and lessons from unicellular organisms may be relevant to multicellular mammals. An understanding of nutrient sensing in general may help in determining how the cell senses changes in phosphate concentration. Summary: Research has yielded important advances in unravelling phosphate sensing and the response to nutrient phosphate supply. However, the actual sensing event for phosphate and most other nutrients must still be defined. Lessons may be learned from those examples in which the sensing event is known, and these are summarized here.

Original languageAmerican English
Pages (from-to)357-361
Number of pages5
JournalCurrent Opinion in Nephrology and Hypertension
Issue number4
StatePublished - Jul 2003


  • NaPi
  • Parathyroid hormone
  • Phosphate


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