Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes

Kfir Sharabi, Emilia Lecuona, Iiro Taneli Helenius, Greg J. Beitel, Jacob Iasha Sznajder, Yosef Gruenbaum*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Carbon dioxide (CO2) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO2 through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO2 is transported into cells, how it is sensed by neurons and other cell types and in understanding the physiological and molecular consequences of elevated CO2 levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. elegans, Drosophila and mice have been proven to be important in understanding of the mechanisms of CO2 sensing and response.

Original languageAmerican English
Pages (from-to)4304-4318
Number of pages15
JournalJournal of Cellular and Molecular Medicine
Issue number11-12
StatePublished - Nov 2009


  • C. elegans neuronal chemosensors
  • CO
  • D. melanogaster
  • Hypercapnia
  • Lungs
  • Signal transduction
  • Soluble adenylate cyclase


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