Sensing, physiological effects and molecular response to elevated CO₂ levels in eukaryotes

Carbon dioxide (CO₂) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO₂ through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO₂ is transported into cells, how it is sensed by neurons and other cell types and in understanding the physiological and molecular consequences of elevated CO₂ levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. elegans, Drosophila and mice have been proven to be important in understanding of the mechanisms of CO₂ sensing and response.