TY - JOUR
T1 - Sensitive Analysis of Nitroguanidine in Aqueous and Soil Matrices by LC-MS
AU - Voloshenko Rossin, Anna
AU - Sladkevich, Sergey
AU - Gasser, Guy
AU - Melman, Artem
AU - Lev, Ovadia
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/9/19
Y1 - 2017/9/19
N2 - Nitroguanidine, a widely used nitramine explosive, is an environmental contaminant that is refractory, persistent, highly mobile in soils and aquifers, and yet under-researched. Nitroguanidine determination in water and soil poses an analytical challenge due its high hydrophilicity, low volatility, charge neutrality over a wide pH range, and low proton affinity which results in low electrospray interface (ESI)-MS sensitivity. A sensitive method for the determination of nitroguanidine in aqueous and soil matrices was developed. The method is based on reduction by zinc in acidic solution, hydrophobization by derivatization, preconcentration on C18 cartridge, and LC-MS quantification. The demonstrated limit of detection (LOD) reaches 5 ng/L and 22 ng/g in water and soil, respectively. Analysis of a contaminated site demonstrates that it is possible to map a contamination plume that extends over 1 km from the source of the contamination.
AB - Nitroguanidine, a widely used nitramine explosive, is an environmental contaminant that is refractory, persistent, highly mobile in soils and aquifers, and yet under-researched. Nitroguanidine determination in water and soil poses an analytical challenge due its high hydrophilicity, low volatility, charge neutrality over a wide pH range, and low proton affinity which results in low electrospray interface (ESI)-MS sensitivity. A sensitive method for the determination of nitroguanidine in aqueous and soil matrices was developed. The method is based on reduction by zinc in acidic solution, hydrophobization by derivatization, preconcentration on C18 cartridge, and LC-MS quantification. The demonstrated limit of detection (LOD) reaches 5 ng/L and 22 ng/g in water and soil, respectively. Analysis of a contaminated site demonstrates that it is possible to map a contamination plume that extends over 1 km from the source of the contamination.
UR - http://www.scopus.com/inward/record.url?scp=85029580874&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.7b02364
DO - 10.1021/acs.analchem.7b02364
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C2 - 28721718
AN - SCOPUS:85029580874
SN - 0003-2700
VL - 89
SP - 9990
EP - 9996
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 18
ER -