Sensitivity to Complex Statistical Regularities in Rat Auditory Cortex

Amit Yaron, Itai Hershenhoren, Israel Nelken*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Neurons in auditory cortex are sensitive to the probability of stimuli: responses to rare stimuli tend to be stronger than responses to common ones. Here, intra- and extracellular recordings from the auditory cortex of halothane-anesthetized rats revealed the existence of a finer sensitivity to the structure of sound sequences. Using oddball sequences in which the order of stimulus presentations is periodic, we found that tones in periodic sequences evoked smaller responses than the same tones in random sequences. Significant reduction in the responses to the common tones in periodic relative to random sequences occurred even when these tones consisted of 95% of the stimuli in the sequence. The reduction in responses paralleled the complexity of the sound sequences and could not be explained by short-term effects of clusters of deviants on succeeding standards. We conclude that neurons in auditory cortex are sensitive to the detailed structure of sound sequences over timescales of minutes.

Original languageAmerican English
Pages (from-to)603-615
Number of pages13
JournalNeuron
Volume76
Issue number3
DOIs
StatePublished - 8 Nov 2012

Bibliographical note

Funding Information:
Support for this research was provided by grants to I.N. from GIF, the German-Israeli Foundation for Scientific Research and Development; the Israel Science Foundation (ISF); the Israeli Ministry of Health under the framework of ERA-Net NEURON; by a generous donation of the Bnei Brith Leo Baeck (London) Lodge; and by the Gatsby Charitable Foundation.

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