Sensory input enhances synaptogenesis of adult-born neurons

Yoav Livneh, Naomi Feinstein, Marguerita Klein, Adi Mizrahi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

88 Scopus citations

Abstract

The adult mammalian brain maintains a prominent stem cell niche in the subventricular zone supplying new neurons to the olfactory bulb. We examined the dynamics of synaptogenesis by imaging the formation and elimination of clusters of a postsynaptic marker (PSD95), genetically targeted to adult-born neurons. We imaged in vivo adult-born periglomerular neurons (PGNs) during two phases of development, immaturity and maturity. Immature PGNs showed high levels of PSD95 puncta dynamics during 12-72 h intervals. Mature PGNs were more stable compared with immature PGNs but still remained dynamic, suggesting that synaptogenesis persists long after these neurons integrated into the network. By combining intrinsic signal and two photon imaging we followed PSD95 puncta in sensory enriched glomeruli. Sensory input upregulated the development of adult-born PGNs only in enriched glomeruli. Our data provide evidence for an activity-based mechanism that enhances synaptogenesis of adult-born PGNs during their initial phases of development.

Original languageAmerican English
Pages (from-to)86-97
Number of pages12
JournalJournal of Neuroscience
Volume29
Issue number1
DOIs
StatePublished - 7 Jan 2009

Keywords

  • Adult-neurogenesis
  • In vivo imaging
  • Olfactory bulb
  • Periglomerular
  • Sensory enrichment
  • Synaptogenesis

Fingerprint

Dive into the research topics of 'Sensory input enhances synaptogenesis of adult-born neurons'. Together they form a unique fingerprint.

Cite this