TY - JOUR
T1 - Sensory-Related Neural Activity Regulates the Structure of Vascular Networks in the Cerebral Cortex
AU - Lacoste, Baptiste
AU - Comin, Cesar H.
AU - Ben-Zvi, Ayal
AU - Kaeser, Pascal S.
AU - Xu, Xiaoyin
AU - Costa, Lucianoda F.
AU - Gu, Chenghua
N1 - Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/9/3
Y1 - 2014/9/3
N2 - Neurovascular interactions are essential for proper brain function. While the effect of neural activity oncerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations ofvascular networks reveals an important feature of neurovascular interactions.
AB - Neurovascular interactions are essential for proper brain function. While the effect of neural activity oncerebral blood flow has been extensively studied, whether or not neural activity influences vascular patterning remains elusive. Here, we demonstrate that neural activity promotes the formation of vascular networks in the early postnatal mouse barrel cortex. Using a combination of genetics, imaging, and computational tools to allow simultaneous analysis of neuronal and vascular components, we found that vascular density and branching were decreased in the barrel cortex when sensory input was reduced by either a complete deafferentation, a genetic impairment of neurotransmitter release at thalamocortical synapses, or a selective reduction of sensory-related neural activity by whisker plucking. In contrast, enhancement of neural activity by whisker stimulation led to an increase in vascular density and branching. The finding that neural activity is necessary and sufficient to trigger alterations ofvascular networks reveals an important feature of neurovascular interactions.
UR - http://www.scopus.com/inward/record.url?scp=84907999477&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2014.07.034
DO - 10.1016/j.neuron.2014.07.034
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C2 - 25155955
AN - SCOPUS:84907999477
SN - 0896-6273
VL - 83
SP - 1117
EP - 1130
JO - Neuron
JF - Neuron
IS - 5
ER -