Separation of a thyroid‐active fraction from unheated soya bean flour

A. M. Konijn*, S. Edelstein, K. Guggenheim

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

An agent depressing thyroid function present in soya beans has been described. It is soluble at pH 4.2, in 2 vol. of acetone and 10% trichloroacetic acid and insoluble in 90% acetone, 90% ethanol and in ethyl ether. It is not precipitated by saturated ammonium sulphate and resists pancreatic digestion and boiling for 2 h, but is apparently destroyed by autoclaving. Evidence of its small molecular weight includes its dialysability and retardation on a Sephadex G25 column. It decreases iodine uptake by the thyroid gland and its incorporation into the diet increases the tri‐iodothyronine‐binding capacity of rat serum.

Original languageEnglish
Pages (from-to)549-555
Number of pages7
JournalJournal of the Science of Food and Agriculture
Volume23
Issue number5
DOIs
StatePublished - May 1972

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