TY - JOUR
T1 - Separation of a thyroid‐active fraction from unheated soya bean flour
AU - Konijn, A. M.
AU - Edelstein, S.
AU - Guggenheim, K.
PY - 1972/5
Y1 - 1972/5
N2 - An agent depressing thyroid function present in soya beans has been described. It is soluble at pH 4.2, in 2 vol. of acetone and 10% trichloroacetic acid and insoluble in 90% acetone, 90% ethanol and in ethyl ether. It is not precipitated by saturated ammonium sulphate and resists pancreatic digestion and boiling for 2 h, but is apparently destroyed by autoclaving. Evidence of its small molecular weight includes its dialysability and retardation on a Sephadex G25 column. It decreases iodine uptake by the thyroid gland and its incorporation into the diet increases the tri‐iodothyronine‐binding capacity of rat serum.
AB - An agent depressing thyroid function present in soya beans has been described. It is soluble at pH 4.2, in 2 vol. of acetone and 10% trichloroacetic acid and insoluble in 90% acetone, 90% ethanol and in ethyl ether. It is not precipitated by saturated ammonium sulphate and resists pancreatic digestion and boiling for 2 h, but is apparently destroyed by autoclaving. Evidence of its small molecular weight includes its dialysability and retardation on a Sephadex G25 column. It decreases iodine uptake by the thyroid gland and its incorporation into the diet increases the tri‐iodothyronine‐binding capacity of rat serum.
UR - http://www.scopus.com/inward/record.url?scp=0015344219&partnerID=8YFLogxK
U2 - 10.1002/jsfa.2740230502
DO - 10.1002/jsfa.2740230502
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C2 - 4114385
AN - SCOPUS:0015344219
SN - 0022-5142
VL - 23
SP - 549
EP - 555
JO - Journal of the Science of Food and Agriculture
JF - Journal of the Science of Food and Agriculture
IS - 5
ER -