Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates

Koyel Banerjee-Ghosh; Oren Ben Dor; Francesco Tassinari; Eyal Capua; Shira Yochelis; Amir Capua; See Hun Yang; Stuart S.P. Parkin; Soumyajit Sarkar; Leeor Kronik; Lech Tomasz Baczewski; Ron Naaman; Yossi Paltiel

doi:10.1126/science.aar4265

Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates

Koyel Banerjee-Ghosh, Oren Ben Dor, Francesco Tassinari, Eyal Capua, Shira Yochelis, Amir Capua, See Hun Yang, Stuart S.P. Parkin, Soumyajit Sarkar, Leeor Kronik, Lech Tomasz Baczewski, Ron Naaman^*, Yossi Paltiel

^*Corresponding author for this work

Department of Applied Physics

Research output: Contribution to journal › Article › peer-review

239 Scopus citations

Abstract

It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.

Original language	American English
Pages (from-to)	1331-1334
Number of pages	4
Journal	Science
Volume	360
Issue number	6395
DOIs	https://doi.org/10.1126/science.aar4265
State	Published - 22 Jun 2018

Bibliographical note

Funding Information:
We thank A. Brandis for performing the HPLC measurements. Y.P. and R.N. acknowledge the support of the John Templeton Foundation. R.N. acknowledges the support of the Israel Science Foundation and the European Research Council under the European Union’s Seventh Framework Program (FP7/2007–2013)–ERC grant agreement n° 338720 CISS. Y.P. acknowledges the support of the Israel Science Foundation and the Ministry of Science Israel. O.B.D. acknowledges support from the Israeli Ministry of Science, Technology, and Space, grant number 0399174. L.T.B. acknowledges institutional support from the Institute of Physics Polish Academy of Sciences.

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© The Authors.

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title = "Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates",

abstract = "It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.",

author = "Koyel Banerjee-Ghosh and Dor, {Oren Ben} and Francesco Tassinari and Eyal Capua and Shira Yochelis and Amir Capua and Yang, {See Hun} and Parkin, {Stuart S.P.} and Soumyajit Sarkar and Leeor Kronik and Baczewski, {Lech Tomasz} and Ron Naaman and Yossi Paltiel",

note = "Funding Information: We thank A. Brandis for performing the HPLC measurements. Y.P. and R.N. acknowledge the support of the John Templeton Foundation. R.N. acknowledges the support of the Israel Science Foundation and the European Research Council under the European Union{\textquoteright}s Seventh Framework Program (FP7/2007–2013)–ERC grant agreement n° 338720 CISS. Y.P. acknowledges the support of the Israel Science Foundation and the Ministry of Science Israel. O.B.D. acknowledges support from the Israeli Ministry of Science, Technology, and Space, grant number 0399174. L.T.B. acknowledges institutional support from the Institute of Physics Polish Academy of Sciences. Publisher Copyright: {\textcopyright} The Authors.",

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doi = "10.1126/science.aar4265",

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AU - Banerjee-Ghosh, Koyel

AU - Dor, Oren Ben

AU - Tassinari, Francesco

AU - Capua, Eyal

AU - Yochelis, Shira

AU - Capua, Amir

AU - Yang, See Hun

AU - Parkin, Stuart S.P.

AU - Sarkar, Soumyajit

AU - Kronik, Leeor

AU - Baczewski, Lech Tomasz

AU - Naaman, Ron

AU - Paltiel, Yossi

N1 - Funding Information: We thank A. Brandis for performing the HPLC measurements. Y.P. and R.N. acknowledge the support of the John Templeton Foundation. R.N. acknowledges the support of the Israel Science Foundation and the European Research Council under the European Union’s Seventh Framework Program (FP7/2007–2013)–ERC grant agreement n° 338720 CISS. Y.P. acknowledges the support of the Israel Science Foundation and the Ministry of Science Israel. O.B.D. acknowledges support from the Israeli Ministry of Science, Technology, and Space, grant number 0399174. L.T.B. acknowledges institutional support from the Institute of Physics Polish Academy of Sciences. Publisher Copyright: © The Authors.

PY - 2018/6/22

Y1 - 2018/6/22

N2 - It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.

AB - It is commonly assumed that recognition and discrimination of chirality, both in nature and in artificial systems, depend solely on spatial effects. However, recent studies have suggested that charge redistribution in chiral molecules manifests an enantiospecific preference in electron spin orientation. We therefore reasoned that the induced spin polarization may affect enantiorecognition through exchange interactions. Here we show experimentally that the interaction of chiral molecules with a perpendicularly magnetized substrate is enantiospecific. Thus, one enantiomer adsorbs preferentially when the magnetic dipole is pointing up, whereas the other adsorbs faster for the opposite alignment of the magnetization. The interaction is not controlled by the magnetic field per se, but rather by the electron spin orientations, and opens prospects for a distinct approach to enantiomeric separations.

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Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates

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