Sequence analysis, endocrine regulation, and signal transduction of GnRH receptors in teleost fish

Berta Levavi-Sivan*, Ayelet Avitan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Three gonadotropin-releasing hormones (GnRHs) and three cognate receptors have been identified in vertebrates, with distinct distributions and functions. According to their sequences, the receptors can be grouped into distinct classes: types I, II, and III. One branch contains all type-I GnRH receptors (GnRH-R-I) from mammals and fish; another branch clusters mainly amphibian and human type-II GnRH receptors; and a third branch includes evolved fish, mainly perciform species, type-III GnRH receptors. Taken tilapia GnRH receptors as a model, the present study summarizes the information regarding the amino-acid residues assumed to be involved in the receptors' structure, binding, activation, and intracellular signal transduction, including arrangement of the disulfide bonds, glycosylation sites, coupling to G proteins, and protein kinase A or protein kinase C phosphorylation sites.

Original languageAmerican English
Pages (from-to)67-73
Number of pages7
JournalGeneral and Comparative Endocrinology
Volume142
Issue number1-2 SPEC. ISS.
DOIs
StatePublished - 15 May 2005

Bibliographical note

Funding Information:
This work was supported by Grant 775/01 from the Israel Science Foundation.

Keywords

  • Disulfide bond
  • G protein
  • GPCR
  • Glycosylation
  • GnRH
  • PKA
  • PKC
  • Phosphorylation
  • Receptor
  • Tilapia

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