Abstract
A formula describing the time-course of activation and desensitization of nicotinic-like acetylcholine channels is developed. The method used to arrive at this simplified formula is based on a sequential approach. Based upon this approximated and simple formula, analytical expressions for various specific experimental aspects are derived. These expressions together with the corresponding experiments provide a method to evaluate in a sequential manner the various rate constants involved.
| Original language | English |
|---|---|
| Pages (from-to) | 381-395 |
| Number of pages | 15 |
| Journal | Journal of Theoretical Biology |
| Volume | 167 |
| Issue number | 4 |
| DOIs | |
| State | Published - 21 Apr 1994 |