Sequential approach to describe the time course of synaptic channel opening under constant transmitter concentration

E. Buchman; H. Parnas

doi:10.1016/S0022-5193(05)80713-1

Sequential approach to describe the time course of synaptic channel opening under constant transmitter concentration

E. Buchman^*
, H. Parnas

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The development of an analytical formula to describe the time course of post-synaptic channel opening under constant low concentrations of neurotransmitter is discussed. Based upon this formula, simplified analytical expressions for the dependence of the rising phase and the steady-state level of open channels on transmitter concentration were produced. These expressions provide the means to evaluate the rate constants which govern the rise time of the synaptic current.

Original language	English
Pages (from-to)	517-534
Number of pages	18
Journal	Journal of Theoretical Biology
Volume	158
Issue number	4
DOIs	https://doi.org/10.1016/S0022-5193(05)80713-1
State	Published - 21 Oct 1992

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abstract = "The development of an analytical formula to describe the time course of post-synaptic channel opening under constant low concentrations of neurotransmitter is discussed. Based upon this formula, simplified analytical expressions for the dependence of the rising phase and the steady-state level of open channels on transmitter concentration were produced. These expressions provide the means to evaluate the rate constants which govern the rise time of the synaptic current.",

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AB - The development of an analytical formula to describe the time course of post-synaptic channel opening under constant low concentrations of neurotransmitter is discussed. Based upon this formula, simplified analytical expressions for the dependence of the rising phase and the steady-state level of open channels on transmitter concentration were produced. These expressions provide the means to evaluate the rate constants which govern the rise time of the synaptic current.

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Sequential approach to describe the time course of synaptic channel opening under constant transmitter concentration

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