Sequential monitoring of clinical trials: The role of information and brownian motion

K. K.Gordon Lan*, David M. Zucker

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Sequential monitoring has been a topic of major interest in clinical trials methodology over the past two decades. This paper presents a unified conceptual framework for sequential monitoring that covers a wide variety of monitoring procedures in a wide variety of clinical trial settings. The central elements of this framework consist of a suitable concept of statistical information and a scheme for using this concept as a basis for summarizing the accumulating results of a trial in a standardized form, through a stochastic process that can be shown to approximate classical Brownian motion. The ideas are developed in a simple step‐by‐step fashion and illustrated by several practical examples.

Original languageAmerican English
Pages (from-to)753-765
Number of pages13
JournalStatistics in Medicine
Volume12
Issue number8
DOIs
StatePublished - 30 Apr 1993

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