TY - JOUR
T1 - Sequential polypeptides by matrix‐controlled thermal polymerization. Synthesis and racemization studies
AU - Sakarellos‐Daitsiotis, Maria
AU - Gilon, Chaim
AU - Sakarellos, Constantinos
AU - Goodman, Murray
PY - 1977/11
Y1 - 1977/11
N2 - A new method for the synthesis of sequential polypeptides is described. The approach consists of the thermal condensation in vacuo of the trifluoroacetate salts of tripeptide pentachlorophenyl esters deposited on a micron‐size celite matrix. The synthesis and polymerization of the trifluoroacetate salts of L‐valy‐L‐valyl‐L‐alanine pentachlorophenyl ester, glycyl‐L‐valyl‐L‐alanine pentachlorophenyl ester, and L‐valyl‐L‐alanylglycine pentachlorophenyl ester are described. High‐molecular‐weight polymers are obtained rapidly in high yield by this method. Comparison of the extents of racemization in the last two polymers constitutes a general approach for assessing racemization during the synthesis of sequential polypeptides since both yield the same polymer, but only the C‐terminal alanine may recemize in the former case.
AB - A new method for the synthesis of sequential polypeptides is described. The approach consists of the thermal condensation in vacuo of the trifluoroacetate salts of tripeptide pentachlorophenyl esters deposited on a micron‐size celite matrix. The synthesis and polymerization of the trifluoroacetate salts of L‐valy‐L‐valyl‐L‐alanine pentachlorophenyl ester, glycyl‐L‐valyl‐L‐alanine pentachlorophenyl ester, and L‐valyl‐L‐alanylglycine pentachlorophenyl ester are described. High‐molecular‐weight polymers are obtained rapidly in high yield by this method. Comparison of the extents of racemization in the last two polymers constitutes a general approach for assessing racemization during the synthesis of sequential polypeptides since both yield the same polymer, but only the C‐terminal alanine may recemize in the former case.
UR - http://www.scopus.com/inward/record.url?scp=0017703141&partnerID=8YFLogxK
U2 - 10.1002/bip.1977.360161113
DO - 10.1002/bip.1977.360161113
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AN - SCOPUS:0017703141
SN - 0006-3525
VL - 16
SP - 2507
EP - 2520
JO - Biopolymers
JF - Biopolymers
IS - 11
ER -