Serial regulation of transcriptional regulators in the yeast cell cycle

Itamar Simon; John Barnett; Nancy Hannett; Christopher T. Harbison; Nicola J. Rinaldi; Thomas L. Volkert; John J. Wyrick; Julia Zeitlinger; David K. Gifford; Tommi S. Jaakkola; Richard A. Young

doi:10.1016/S0092-8674(01)00494-9

Serial regulation of transcriptional regulators in the yeast cell cycle

Itamar Simon, John Barnett, Nancy Hannett, Christopher T. Harbison, Nicola J. Rinaldi, Thomas L. Volkert, John J. Wyrick, Julia Zeitlinger, David K. Gifford, Tommi S. Jaakkola, Richard A. Young^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

521 Scopus citations

Abstract

Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.

Original language	English
Pages (from-to)	697-708
Number of pages	12
Journal	Cell
Volume	106
Issue number	6
DOIs	https://doi.org/10.1016/S0092-8674(01)00494-9
State	Published - 21 Sep 2001
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to Pronob Bardhan, Thomas Hinman, and Uwe Muller for encouraging and supporting this study. We thank Steve Bell, Angelika Amon, and Gerry Fink for advice and comments on the manuscript, Kim Nasmyth for reagents, and Ezra Jennings, Joerg Schreiber, and Elenita Kanin for technical assistance. Supported by funds from Corning, Inc., NIH, European Molecular Biology Organization (I.S.), NSF (J.J.W.), and the Human Frontier Science Program (J.Z.).

Access to Document

10.1016/S0092-8674(01)00494-9

Cite this

@article{158826c7c87a401cb05af111a7c97f89,

title = "Serial regulation of transcriptional regulators in the yeast cell cycle",

abstract = "Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.",

author = "Itamar Simon and John Barnett and Nancy Hannett and Harbison, {Christopher T.} and Rinaldi, {Nicola J.} and Volkert, {Thomas L.} and Wyrick, {John J.} and Julia Zeitlinger and Gifford, {David K.} and Jaakkola, {Tommi S.} and Young, {Richard A.}",

note = "Funding Information: We are grateful to Pronob Bardhan, Thomas Hinman, and Uwe Muller for encouraging and supporting this study. We thank Steve Bell, Angelika Amon, and Gerry Fink for advice and comments on the manuscript, Kim Nasmyth for reagents, and Ezra Jennings, Joerg Schreiber, and Elenita Kanin for technical assistance. Supported by funds from Corning, Inc., NIH, European Molecular Biology Organization (I.S.), NSF (J.J.W.), and the Human Frontier Science Program (J.Z.).",

year = "2001",

month = sep,

day = "21",

doi = "10.1016/S0092-8674(01)00494-9",

language = "אנגלית",

volume = "106",

pages = "697--708",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "6",

}

TY - JOUR

T1 - Serial regulation of transcriptional regulators in the yeast cell cycle

AU - Simon, Itamar

AU - Barnett, John

AU - Hannett, Nancy

AU - Harbison, Christopher T.

AU - Rinaldi, Nicola J.

AU - Volkert, Thomas L.

AU - Wyrick, John J.

AU - Zeitlinger, Julia

AU - Gifford, David K.

AU - Jaakkola, Tommi S.

AU - Young, Richard A.

N1 - Funding Information: We are grateful to Pronob Bardhan, Thomas Hinman, and Uwe Muller for encouraging and supporting this study. We thank Steve Bell, Angelika Amon, and Gerry Fink for advice and comments on the manuscript, Kim Nasmyth for reagents, and Ezra Jennings, Joerg Schreiber, and Elenita Kanin for technical assistance. Supported by funds from Corning, Inc., NIH, European Molecular Biology Organization (I.S.), NSF (J.J.W.), and the Human Frontier Science Program (J.Z.).

PY - 2001/9/21

Y1 - 2001/9/21

N2 - Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.

AB - Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.

UR - http://www.scopus.com/inward/record.url?scp=17944372930&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(01)00494-9

DO - 10.1016/S0092-8674(01)00494-9

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 11572776

AN - SCOPUS:17944372930

SN - 0092-8674

VL - 106

SP - 697

EP - 708

JO - Cell

JF - Cell

IS - 6

ER -

Serial regulation of transcriptional regulators in the yeast cell cycle

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this