Serial regulation of transcriptional regulators in the yeast cell cycle

Itamar Simon, John Barnett, Nancy Hannett, Christopher T. Harbison, Nicola J. Rinaldi, Thomas L. Volkert, John J. Wyrick, Julia Zeitlinger, David K. Gifford, Tommi S. Jaakkola, Richard A. Young*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

518 Scopus citations

Abstract

Genome-wide location analysis was used to determine how the yeast cell cycle gene expression program is regulated by each of the nine known cell cycle transcriptional activators. We found that cell cycle transcriptional activators that function during one stage of the cell cycle regulate transcriptional activators that function during the next stage. This serial regulation of transcriptional activators forms a connected regulatory network that is itself a cycle. Our results also reveal how the nine transcriptional regulators coordinately regulate global gene expression and diverse stage-specific functions to produce a continuous cycle of cellular events. This information forms the foundation for a complete map of the transcriptional regulatory network that controls the cell cycle.

Original languageAmerican English
Pages (from-to)697-708
Number of pages12
JournalCell
Volume106
Issue number6
DOIs
StatePublished - 21 Sep 2001
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Pronob Bardhan, Thomas Hinman, and Uwe Muller for encouraging and supporting this study. We thank Steve Bell, Angelika Amon, and Gerry Fink for advice and comments on the manuscript, Kim Nasmyth for reagents, and Ezra Jennings, Joerg Schreiber, and Elenita Kanin for technical assistance. Supported by funds from Corning, Inc., NIH, European Molecular Biology Organization (I.S.), NSF (J.J.W.), and the Human Frontier Science Program (J.Z.).

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