Serine/threonine protein kinases and phosphatases in filamentious fungi

Martin B. Dickman*, Oded Yarden

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

134 Scopus citations


Protein phosphorylation and dephosphorylation are one of the central currencies by which living cells perceive and respond to environmental cues. A number of fundamental processes in fungi such as the cell cycle, transcription, and mating have been shown to require protein phosphorylation. The analysis of protein kinases and phosphatases in filamentous fungi is in its infancy; however, it has already become clear that kinases and phosphatases are likely to be important mediators of fungal proliferation and development as well as signal transduction and infection-related morphogenesis. In this review, we describe, summarize, and consider the rapidly expanding field of protein phosphorylation/dephosphorylation in various aspects of filamentous fungal growth and development.

Original languageAmerican English
Pages (from-to)99-117
Number of pages19
JournalFungal Genetics and Biology
Issue number2
StatePublished - Mar 1999

Bibliographical note

Funding Information:
We thank Viktor Dombradi, Jim Kronstad, and Greg May for providing unpublished information and Talma Katan for her critical comments and discussions concerning this manuscript. The authors work has been supported, in part, by BARD the U.S.–Israel Binational Agricultural Research and Development fund.


  • Fungal genes
  • Fungal growth
  • Fungal morphogenesis
  • Gene regulation
  • Protein phosphorylation
  • Signal transduction


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