Serological evaluation of cutaneous leishmania tropica infection in Northern Israel

Iva Rohousova, Dalit Talmi-Frank, Michaela Vlkova, Tatiana Spitzova, Koranit Rishpon, Charles L. Jaffe, Petr Volf, Gad Baneth*, Moshe Ephros

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Leishmania spp. are medically important unicellular parasites transmitted by phlebotomine sand flies. The World Health Organization recently highlighted the importance of reliable diagnostic tools for leishmaniasis. Our study of human infection was conducted in two endemic foci of Leishmania tropica in the Galilee region, northern Israel. Elevated anti-Leishmania antibodies were present in the majority (78.6%) of L. tropica-PCR positive individuals. Moreover, the enzyme-linked immunosorbent assay showed high sensitivity, specificity, and negative and positive predictive values (ranging between 73% and 79%), thus fulfilling the basic requirement for future development of a serodiagnostic and screening tool. The anti-sand fly saliva antibodies used as biomarkers of exposure reflected the composition of the local sand fly fauna as well as the abundance of individual species. High levels of antibodies against vector salivary proteins may further indicate frequent exposure to sand flies and consequently a higher probability of Leishmania transmission.

Original languageAmerican English
Pages (from-to)139-141
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume98
Issue number1
DOIs
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 by The American Society of Tropical Medicine and Hygiene.

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