TY - JOUR
T1 - Serum ferritin and paraoxonase-1 in canine leishmaniosis
AU - Martinez-Subiela, S.
AU - Cerón, J. J.
AU - Strauss-Ayali, D.
AU - Garcia-Martinez, J. D.
AU - Tecles, F.
AU - Tvarijonaviciute, A.
AU - Caldin, M.
AU - Baneth, G.
PY - 2014/1
Y1 - 2014/1
N2 - Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored for 7 months post-infection, then treated for 3 months with allopurinol, and their response to therapy was followed for 11 additional months. Naturally-infected dogs were staged based on the urine protein/creatinine (UPC) ratio into three groups as follows: group 1 (non-proteinuric; UPC ratio: <0.2), group 2 (borderline proteinuric; UPC ratio: 0.2-0.5) and group 3 (proteinuric; UPC ratio >0.5). An increase in serum ferritin values and a decrease in PON-1 activity were observed 2 months after infection. Both analytes returned to preinfection values following treatment. Significantly higher concentrations of ferritin were observed in dogs classified as either borderline or proteinuric when compared with non-proteinuric dogs whereas serum PON-1 activity was decreased only in proteinuric dogs.
AB - Ferritin and paraoxonase-1 (PON-1) were measured in dogs experimentally infected by Leishmania infantum (during experimental infection and following treatment) and also in naturally-infected dogs which presented different degrees of proteinuria. Experimentally-infected dogs were monitored for 7 months post-infection, then treated for 3 months with allopurinol, and their response to therapy was followed for 11 additional months. Naturally-infected dogs were staged based on the urine protein/creatinine (UPC) ratio into three groups as follows: group 1 (non-proteinuric; UPC ratio: <0.2), group 2 (borderline proteinuric; UPC ratio: 0.2-0.5) and group 3 (proteinuric; UPC ratio >0.5). An increase in serum ferritin values and a decrease in PON-1 activity were observed 2 months after infection. Both analytes returned to preinfection values following treatment. Significantly higher concentrations of ferritin were observed in dogs classified as either borderline or proteinuric when compared with non-proteinuric dogs whereas serum PON-1 activity was decreased only in proteinuric dogs.
KW - Dog
KW - Ferritin
KW - Leishmaniosis
KW - Paraoxonase-1
UR - http://www.scopus.com/inward/record.url?scp=84890919744&partnerID=8YFLogxK
U2 - 10.1016/j.cimid.2013.10.004
DO - 10.1016/j.cimid.2013.10.004
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C2 - 24268430
AN - SCOPUS:84890919744
SN - 0147-9571
VL - 37
SP - 23
EP - 29
JO - Comparative Immunology, Microbiology and Infectious Diseases
JF - Comparative Immunology, Microbiology and Infectious Diseases
IS - 1
ER -