TY - JOUR
T1 - Serum Ferritin Levels in Preterm Infants after Multiple Blood Transfusions
AU - Arad, Ilan
AU - Konijn, Avraham M.
AU - Linder, Nechama
AU - Goldstein, Mara
AU - Kaufmann, Nathan A.
PY - 1988/1
Y1 - 1988/1
N2 - We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge. Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively). At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 ±g/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 ±g/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 ±g/L) or group C who received less than 100 ml (36.5 ± 8.8 ±g/L packed red blood cells. However, these differences were not statistically significant. Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life. Administration of large amounts of supplemental iron, in such cases, may be curtailed.
AB - We have examined the effect on iron stores of blood transfusions given to premature neonates during hospitalization in the neonatal intensive care unit as reflected by serum ferritin levels measured for 6 months after discharge. Premature infants who were transfused with more than 100 ml packed cells (group D; n = 11) had higher ferritin levels for a longer period than premature infants who were transfused with smaller volumes (group c; n = 9) or premature and mature infants who were not transfused at all (group B; n = 24 and group A; n = 21, respectively). At 4-5 months the serum ferritin levels in group D (489.8 ± 132.1 ±g/L; mean ± SEM) were significantly higher (P < 0.001) than those of the other groups. The level of group A term infants (77.5 ±12.5 ±g/L) was higher than those of group B premature infants who did not receive a blood transfusion (33.0 ± 7.1 ±g/L) or group C who received less than 100 ml (36.5 ± 8.8 ±g/L packed red blood cells. However, these differences were not statistically significant. Our data demonstrate that very-low-birthweight infants who receive a large volume of packed cells during hospitalization may accumulate iron stores sufficient for red cell production during the first 6 months of life. Administration of large amounts of supplemental iron, in such cases, may be curtailed.
UR - http://www.scopus.com/inward/record.url?scp=0023818673&partnerID=8YFLogxK
U2 - 10.1055/s-2007-999651
DO - 10.1055/s-2007-999651
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C2 - 3337757
AN - SCOPUS:0023818673
SN - 0735-1631
VL - 5
SP - 40
EP - 43
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 1
ER -