TY - JOUR
T1 - Serum prolactin in coeliac disease
T2 - A marker for disease activity
AU - Reifen, Ram
AU - Buskila, Dan
AU - Maislos, Moshe
AU - Press, Joseph
AU - Lerner, Aaron
PY - 1997
Y1 - 1997
N2 - Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.
AB - Prolactin, a polypeptide hormone of anterior pituitary origin, has pronounced physiological effects on growth, reproduction, and osmoregulation. Increasing evidence indicates that prolactin also has an immunomodulatory influence on the immune system. The status of prolactin in patients with coellac disease was investigated by obtaining serum samples from 48 patients with active and non-active coeliac disease. These were compared with samples from 20 children with familial Mediterranean fever and 65 normal controls. Serum prolactin in patients with active coeliac disease was significantly higher than in the other groups studied and reference values. Serum prolactin correlated well with the degree of mucosal atrophy and with the serum concentration of antiendomysial antibodies. Prolactin may play a part in immune modulation in the intestinal damage of coeliac disease and serve as a potential marker for disease activity.
KW - Coeliac disease
KW - Prolactin
UR - http://www.scopus.com/inward/record.url?scp=0030961038&partnerID=8YFLogxK
U2 - 10.1136/adc.77.2.155
DO - 10.1136/adc.77.2.155
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AN - SCOPUS:0030961038
SN - 0003-9888
VL - 77
SP - 155
EP - 157
JO - Archives of Disease in Childhood
JF - Archives of Disease in Childhood
IS - 2
ER -