Serum vasoactive prostaglandins; TNFα and magnesium, in hypertensive psoriatics undergoing climatotherapy at the Dead-Sea

R. Barzillai*, J. Shani, I. Katzir, E. Shohami, V. Trembovler, E. Hristekieva, M. Harari, A. Ingber

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Recent reports demonstrated a sustained decrease in blood pressure in hypertensive psoriatics, of both sexes and in all age groups, after a four-week climatotherapy at the Dead-Sea. Some of the factors that could have been involved in this effect are levels of ionic magnesium and calcium inhaled, serum levels of vasoconstrictor and vasodilator prostaglandines and TNF-alpha. The objective of the present study was to look for a possible correlation between the drop of systolic and diastolic blood pressure in hypertensive psoriatics, and their changes in serum levels of TXB2, PGE2, 6-keto-PGF and TNFα, as well as of inhaled ionic magnesium and calcium. While the serum levels of the vasoconstricting prostaglandin TXB2 dropped after two weeks of climatotherapy, those of the vasodilating prostaglandines PGE2 and 6-keto-PGF increased during these two weeks. The levels of the three prostaglandines returned gradually to their pretreatment levels towards the end of the 4-week stay. A rapid drop was recorded in the levels of TNFα. There was no change in the serum levels of ionic magnesium and calcium. In conclusion, the levels of these three prostaglandines, and of TNFα, are sensitive parameters to predict and follow-up the drop in systolic and diastolic blood pressure in hypertensive psoriatics undergoing climatotherapy at the Dead-sea.

Original languageEnglish
Pages (from-to)131-141
Number of pages11
JournalPharmacology Reviews and Communications
Volume11
Issue number2
StatePublished - 2001

Keywords

  • Blood pressure
  • Climatotherapy
  • Dead-Sea
  • Hypertension
  • Ionic calcium
  • Ionic magnesium
  • Prostaglandines
  • Psoriasis
  • Thromboxane
  • TNF

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