Setting global standards for stem cell research and clinical translation: The 2016 ISSCR guidelines

George Q. Daley*, Insoo Hyun, Jane F. Apperley, Roger A. Barker, Nissim Benvenisty, Annelien L. Bredenoord, Christopher K. Breuer, Timothy Caulfield, Marcelle I. Cedars, Joyce Frey-Vasconcells, Helen E. Heslop, Ying Jin, Richard T. Lee, Christopher McCabe, Megan Munsie, Charles E. Murry, Steven Piantadosi, Mahendra Rao, Heather M. Rooke, Douglas SippLorenz Studer, Jeremy Sugarman, Masayo Takahashi, Mark Zimmerman, Jonathan Kimmelman

*Corresponding author for this work

Research output: Contribution to journalComment/debate

155 Scopus citations


The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the revision and extension of two past sets of guidelines (ISSCR, 2006; ISSCR, 2008) to address new and emerging areas of stem cell discovery and application and evolving ethical, social, and policy challenges. These guidelines provide an integrated set of principles and best practices to drive progress in basic, translational, and clinical research. The guidelines demand rigor, oversight, and transparency in all aspects of practice, providing confidence to practitioners and public alike that stem cell science can proceed efficiently and remain responsive to public and patient interests. Here, we highlight key elements and recommendations in the guidelines and summarize the recommendations and deliberations behind them.

Original languageAmerican English
Pages (from-to)787-797
Number of pages11
JournalStem Cell Reports
Issue number6
StatePublished - 14 Jun 2016

Bibliographical note

Publisher Copyright:
© 2016 The Author(s).


  • EMRO
  • clinical translation
  • clinical trials
  • communication
  • embryo research
  • guidelines
  • stem cells


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