Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization After Messenger RNA Vaccination and Variant Breakthrough Infection

Christian Gaebler, Justin Dasilva, Eva Bednarski, Frauke Muecksch, Fabian Schmidt, Yiska Weisblum, Katrina G. Millard, Martina Turroja, Alice Cho, Zijun Wang, Marina Caskey, Michel C. Nussenzweig, Paul D. Bieniasz, Theodora Hatziioannou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.

Original languageEnglish
Article numberofac227
JournalOpen Forum Infectious Diseases
Volume9
Issue number7
DOIs
StatePublished - 1 Jul 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords

  • Breakthrough infection
  • Neutralization
  • Omicron
  • SARS-CoV-2
  • Vaccination

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