Abstract
The emergence of severe acute respiratory syndrome coronavirus 2 variants that have greater transmissibility and resistance to neutralizing antibodies has increased the incidence of breakthrough infections. We show that breakthrough infection increases neutralizing antibody titers to varying degrees depending on the nature of the breakthrough variant and the number of vaccine doses previously administered. Omicron breakthrough infection resulted in neutralizing antibody titers that were the highest across all groups, particularly against Omicron.
Original language | English |
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Article number | ofac227 |
Journal | Open Forum Infectious Diseases |
Volume | 9 |
Issue number | 7 |
DOIs | |
State | Published - 1 Jul 2022 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2022 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Keywords
- Breakthrough infection
- Neutralization
- Omicron
- SARS-CoV-2
- Vaccination