Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task

Mark J. Wagner; Tony Hyun Kim; Jonathan Kadmon; Nghia D. Nguyen; Surya Ganguli; Mark J. Schnitzer; Liqun Luo

doi:10.1016/j.cell.2019.02.019

Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task

Mark J. Wagner^*, Tony Hyun Kim, Jonathan Kadmon, Nghia D. Nguyen, Surya Ganguli, Mark J. Schnitzer, Liqun Luo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Simultaneous recordings of ensembles of individual neurons in the neocortex and cerebellum provide a view of how these two brain regions learn together.

Original language	American English
Pages (from-to)	669-682.e24
Journal	Cell
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.02.019
State	Published - 18 Apr 2019
Externally published	Yes

Bibliographical note

Funding Information:
We thank J. Lecoq for microscope design; C. Ramakrishnan and K. Deisseroth for opsin plasmids; members of the Luo laboratory for reagents and helpful discussions; J.H. Lui for mice; S. Haziza for experimental assistance; and J. Raymond, S. Druckmann, K. Shenoy, and C.K. Kim for critical comments on the manuscript. M.J.W. was supported by the Epilepsy Training Grant . M.J.S. and L.L. are HHMI investigators. This work was supported by NIH grants R01 NS050835 and R01 NS104698 and an NSF NeuroNex grant.

Funding Information:
We thank J. Lecoq for microscope design; C. Ramakrishnan and K. Deisseroth for opsin plasmids; members of the Luo laboratory for reagents and helpful discussions; J.H. Lui for mice; S. Haziza for experimental assistance; and J. Raymond, S. Druckmann, K. Shenoy, and C.K. Kim for critical comments on the manuscript. M.J.W. was supported by the Epilepsy Training Grant. M.J.S. and L.L. are HHMI investigators. This work was supported by NIH grants R01 NS050835 and R01 NS104698 and an NSF NeuroNex grant. M.J.W. and L.L. designed the experiments. M.J.W. performed experiments and analyzed the data with help from T.H.K. and N.D.N. T.H.K. designed the multi-access optical strategy and performed Ca2+ data processing. J.K. and S.G. performed simulations and data analysis. M.J.S. contributed imaging hardware, software, and expertise. L.L. supervised the project. All authors contributed to writing the manuscript. The authors declare no competing interests.

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

brain state
cerebellum
dimensional expansion
granule cells
layer 5
motor learning
movement planning
neocortex
pontine nuclei
reward

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10.1016/j.cell.2019.02.019

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title = "Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task",

abstract = "Simultaneous recordings of ensembles of individual neurons in the neocortex and cerebellum provide a view of how these two brain regions learn together.",

keywords = "brain state, cerebellum, dimensional expansion, granule cells, layer 5, motor learning, movement planning, neocortex, pontine nuclei, reward",

author = "Wagner, {Mark J.} and Kim, {Tony Hyun} and Jonathan Kadmon and Nguyen, {Nghia D.} and Surya Ganguli and Schnitzer, {Mark J.} and Liqun Luo",

note = "Funding Information: We thank J. Lecoq for microscope design; C. Ramakrishnan and K. Deisseroth for opsin plasmids; members of the Luo laboratory for reagents and helpful discussions; J.H. Lui for mice; S. Haziza for experimental assistance; and J. Raymond, S. Druckmann, K. Shenoy, and C.K. Kim for critical comments on the manuscript. M.J.W. was supported by the Epilepsy Training Grant . M.J.S. and L.L. are HHMI investigators. This work was supported by NIH grants R01 NS050835 and R01 NS104698 and an NSF NeuroNex grant. Funding Information: We thank J. Lecoq for microscope design; C. Ramakrishnan and K. Deisseroth for opsin plasmids; members of the Luo laboratory for reagents and helpful discussions; J.H. Lui for mice; S. Haziza for experimental assistance; and J. Raymond, S. Druckmann, K. Shenoy, and C.K. Kim for critical comments on the manuscript. M.J.W. was supported by the Epilepsy Training Grant. M.J.S. and L.L. are HHMI investigators. This work was supported by NIH grants R01 NS050835 and R01 NS104698 and an NSF NeuroNex grant. M.J.W. and L.L. designed the experiments. M.J.W. performed experiments and analyzed the data with help from T.H.K. and N.D.N. T.H.K. designed the multi-access optical strategy and performed Ca2+ data processing. J.K. and S.G. performed simulations and data analysis. M.J.S. contributed imaging hardware, software, and expertise. L.L. supervised the project. All authors contributed to writing the manuscript. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

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Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task

Abstract

Bibliographical note

Keywords

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