Sialochemistry and cortisol levels in patients with Sjogren's syndrome

B. E. Miller, O. Deutsch, M. Redlich, Y. T. Konttinen, R. Benoliel, B. Zaks, E. Davidovich, A. Palmon, D. J. Aframian*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objectives: (i) To determine whether salivary cortisol and electrolyte levels differ between patients with Sjogren's syndrome (SjS) and healthy individuals. (ii) To assess correlations between whole-saliva cortisol and some clinical manifestations in patients with SjS. Methods: A total of 24 healthy women (mean age 49.3±9.8) served as controls (C) vis-à-vis 17 patients with SjS (mean age 55.5±15.7). Salivary cortisol concentration was determined, and sialochemistry analysis was performed. Results: Significantly lower saliva flow rates and higher salivary chloride (Cl -), potassium (K +), and Ca 2+ levels were found in the SjS group. No significant differences or correlations were found in other parameters, including sodium (Na +), magnesium (Mg 2+), phosphate ( -), urea (U), and salivary cortisol levels. Conclusion: Increased whole-salivary output of Cl - and K + in SjS may reflect release from apoptotic rests of acinar cells after secondary necrosis. Normal levels of salivary Na +, Mg 2+, and - argue against concentration effect, deranged tubular function or cortisol (mineralocorticosteroid) effect as the cause for these findings. Increased salivary Ca 2+ levels probably reflect leakage of plasma Ca 2+ through the injured oral mucosa in SjS. In spite of disease-associated stress, salivary cortisol, a stress biomarker, was not increased, suggesting insufficient hypothalamus-pituitary-adrenal (HPA) axis response and/or local consumption of cortisol by lymphocyte infiltrates.

Original languageAmerican English
Pages (from-to)255-259
Number of pages5
JournalOral Diseases
Issue number3
StatePublished - Apr 2012


  • Cortisol
  • Saliva
  • Sjogren's syndrome


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