TY - JOUR
T1 - Signal‐Transduction Therapy
T2 - A Novel Approach to Disease Management
AU - Levitzki, Alexander
PY - 1994/11
Y1 - 1994/11
N2 - In the past decade it has become apparent that many diseases result from aberrations in signaling pathways. These include proliferative diseases such as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept cell signaling. In this review, the emerging success in using tyrosine kinase blockers and other signal interceptors, such as protein kinase C blockers, Ras blockers, Ca2+ signaling inhibitors and estrogen antagonists which inhibit growth of cancer cells in vitro and in vivo, will be discussed. These signal interceptors, especially tyrosine‐kinase blockers, are also able to block inflammatory responses and the proliferation of vascular smooth muscle cells and psoriatic keratinocytes. The utility of signal interceptors in analyzing signal‐transduction pathways is also discussed.
AB - In the past decade it has become apparent that many diseases result from aberrations in signaling pathways. These include proliferative diseases such as cancers, atherosclerosis and psoriasis and inflammatory conditions such as sepsis, rheumatoid arthritis and tissue rejection. These findings refocused the research of the medical community to seek new modalities for disease management which essentially consist of designing drugs which intercept cell signaling. In this review, the emerging success in using tyrosine kinase blockers and other signal interceptors, such as protein kinase C blockers, Ras blockers, Ca2+ signaling inhibitors and estrogen antagonists which inhibit growth of cancer cells in vitro and in vivo, will be discussed. These signal interceptors, especially tyrosine‐kinase blockers, are also able to block inflammatory responses and the proliferation of vascular smooth muscle cells and psoriatic keratinocytes. The utility of signal interceptors in analyzing signal‐transduction pathways is also discussed.
UR - http://www.scopus.com/inward/record.url?scp=0028000069&partnerID=8YFLogxK
U2 - 10.1111/j.1432-1033.1994.tb20020.x
DO - 10.1111/j.1432-1033.1994.tb20020.x
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C2 - 7957236
AN - SCOPUS:0028000069
SN - 0014-2956
VL - 226
SP - 1
EP - 13
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 1
ER -