Significance level in interval mapping

David O. Siegmund, Benny Yakir

Research output: Chapter in Book/Report/Conference proceedingChapter


The false positive rate of a genome scan that uses interval mapping involves the
distribution of the maximum of a Gaussian process, for which there are two approximations: one relying on the Rice-Davies formula, which is accurate for relatively sparsely placed markers, and one that is accurate for closely spaced markers. In this paper we combine these two approximations to obtain an approximation that is accurate for both sparse and dense markers. We also give a new proof of the Rice-Davies formula.
Original languageAmerican English
Title of host publicationDevelopment of Modern Statistics and Related Topics
Subtitle of host publicationIn Celebration Of Prof Yaoting Zhang's 70th Birthday
EditorsJian Huang, Heping Zhang
Place of PublicationRiver Edge, NJ
PublisherWorld Scientific
ISBN (Electronic)1-281-95609-0
StatePublished - 2003

Publication series

Name Series in Biostatistics


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