Silence of the genes - Mechanisms of long-term repression

Laura Lande-Diner, Howard Cedar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations

Abstract

A large fraction of genes in the mammalian genome is repressed in every cell throughout development. Here, we propose that this long-term silencing is carried out by distinct molecular mechanisms that operate in a global manner and, once established, can be maintained autonomously through DNA replication. Both individually and in combination these mechanisms bring about repression, mainly by lowering gene accessibility through closed chromatin structures.

Original languageEnglish
Pages (from-to)648-654
Number of pages7
JournalNature Reviews Genetics
Volume6
Issue number8
DOIs
StatePublished - Aug 2005

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