Abstract
Three 5(p-trimethylsilylphenyl)barbiturates and one related thiobarbiturate were prepared starting from ptrimethylsilylphenylacetic acid, which was converted to diethyl alkyl-p-trimethylsilylphenylmalonates and condensed with urea or thiourea. Preliminary pharmacological evaluation of these barbiturates, as well as of two 5-(p-trimethylsilylbenzyl)barbiturates, showed them to have low sedative activity. Some of the compounds showed anticonvulsant activity.
| Original language | English |
|---|---|
| Pages (from-to) | 92-94 |
| Number of pages | 3 |
| Journal | Journal of Medicinal Chemistry |
| Volume | 11 |
| Issue number | 1 |
| DOIs | |
| State | Published - 1 Jan 1968 |