Silicon-Containing Barbiturates

Igal Belsky; David Gertner; Albert Zilkha

doi:10.1021/jm00307a020

Silicon-Containing Barbiturates

Igal Belsky
, David Gertner
, Albert Zilkha

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Three 5(p-trimethylsilylphenyl)barbiturates and one related thiobarbiturate were prepared starting from ptrimethylsilylphenylacetic acid, which was converted to diethyl alkyl-p-trimethylsilylphenylmalonates and condensed with urea or thiourea. Preliminary pharmacological evaluation of these barbiturates, as well as of two 5-(p-trimethylsilylbenzyl)barbiturates, showed them to have low sedative activity. Some of the compounds showed anticonvulsant activity.

Original language	English
Pages (from-to)	92-94
Number of pages	3
Journal	Journal of Medicinal Chemistry
Volume	11
Issue number	1
DOIs	https://doi.org/10.1021/jm00307a020
State	Published - 1 Jan 1968

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AB - Three 5(p-trimethylsilylphenyl)barbiturates and one related thiobarbiturate were prepared starting from ptrimethylsilylphenylacetic acid, which was converted to diethyl alkyl-p-trimethylsilylphenylmalonates and condensed with urea or thiourea. Preliminary pharmacological evaluation of these barbiturates, as well as of two 5-(p-trimethylsilylbenzyl)barbiturates, showed them to have low sedative activity. Some of the compounds showed anticonvulsant activity.

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Silicon-Containing Barbiturates

Abstract

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