SIMILARITY BETWEEN RECEPTORS RESPONSIBLE FOR THE PRODUCTION OF ANALGESIA AND LENTICULAR OPACITY

MARTA WEINSTOCK

doi:10.1111/j.1476-5381.1961.tb01130.x

SIMILARITY BETWEEN RECEPTORS RESPONSIBLE FOR THE PRODUCTION OF ANALGESIA AND LENTICULAR OPACITY

MARTA WEINSTOCK^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Evidence is presented that the receptors responsible for the mediation of analgesia by morphine‐like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with d configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished. 1961 British Pharmacological Society

Original language	English
Pages (from-to)	433-441
Number of pages	9
Journal	British journal of pharmacology and chemotherapy
Volume	17
Issue number	3
DOIs	https://doi.org/10.1111/j.1476-5381.1961.tb01130.x
State	Published - Dec 1961
Externally published	Yes

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title = "SIMILARITY BETWEEN RECEPTORS RESPONSIBLE FOR THE PRODUCTION OF ANALGESIA AND LENTICULAR OPACITY",

abstract = "Evidence is presented that the receptors responsible for the mediation of analgesia by morphine‐like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with d configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished. 1961 British Pharmacological Society",

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SIMILARITY BETWEEN RECEPTORS RESPONSIBLE FOR THE PRODUCTION OF ANALGESIA AND LENTICULAR OPACITY

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