Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders

Simons Vip Consortium

doi:10.1016/j.neuron.2012.02.014

Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders

Simons Vip Consortium

School of Occupational Therapy

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.

Original language	English
Pages (from-to)	1063-7
Number of pages	5
Journal	Neuron
Volume	73
Issue number	6
DOIs	https://doi.org/10.1016/j.neuron.2012.02.014
State	Published - 22 Mar 2012

Bibliographical note

Keywords

Adolescent
Child
Child Development Disorders, Pervasive/diagnosis
Child, Preschool
Chromosome Deletion
Chromosomes, Human, Pair 16/genetics
Developmental Disabilities/diagnosis
Family Health
Female
Genetic Predisposition to Disease/genetics
Genetic Testing
Humans
Infant
Information Dissemination
Male
Neurodegenerative Diseases/diagnosis
Neuroimaging
Neurophysiology
Phenotype
Retrospective Studies

Access to Document

10.1016/j.neuron.2012.02.014

Cite this

@article{a9dc7d6cd7884e42b2b7ee3b0419b689,

title = "Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders",

abstract = "We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.",

keywords = "Adolescent, Child, Child Development Disorders, Pervasive/diagnosis, Child, Preschool, Chromosome Deletion, Chromosomes, Human, Pair 16/genetics, Developmental Disabilities/diagnosis, Family Health, Female, Genetic Predisposition to Disease/genetics, Genetic Testing, Humans, Infant, Information Dissemination, Male, Neurodegenerative Diseases/diagnosis, Neuroimaging, Neurophysiology, Phenotype, Retrospective Studies",

author = "\{Simons Vip Consortium\} and Benjamin Aaronson",

year = "2012",

month = mar,

day = "22",

doi = "10.1016/j.neuron.2012.02.014",

language = "אנגלית",

volume = "73",

pages = "1063--7",

journal = "Neuron",

issn = "0896-6273",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Simons Variation in Individuals Project (Simons VIP)

T2 - a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders

AU - Simons Vip Consortium

AU - Aaronson, Benjamin

PY - 2012/3/22

Y1 - 2012/3/22

N2 - We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.

AB - We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.

KW - Adolescent

KW - Child

KW - Child Development Disorders, Pervasive/diagnosis

KW - Child, Preschool

KW - Chromosome Deletion

KW - Chromosomes, Human, Pair 16/genetics

KW - Developmental Disabilities/diagnosis

KW - Family Health

KW - Female

KW - Genetic Predisposition to Disease/genetics

KW - Genetic Testing

KW - Humans

KW - Infant

KW - Information Dissemination

KW - Male

KW - Neurodegenerative Diseases/diagnosis

KW - Neuroimaging

KW - Neurophysiology

KW - Phenotype

KW - Retrospective Studies

UR - http://www.scopus.com/inward/record.url?scp=84858673064&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2012.02.014

DO - 10.1016/j.neuron.2012.02.014

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 22445335

SN - 0896-6273

VL - 73

SP - 1063

EP - 1067

JO - Neuron

JF - Neuron

IS - 6

ER -

Simons Variation in Individuals Project (Simons VIP): a genetics-first approach to studying autism spectrum and related neurodevelopmental disorders

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this