Abstract
We describe a project aimed at studying a large number of individuals (>200) with specific recurrent genetic variations (deletion or duplication of segment 16p11.2) that increase the risk of developing autism spectrum (ASD) and other developmental disorders. The genetics-first approach augmented by web-based recruitment, multisite collaboration and calibration, and robust data-sharing policies could be adopted by other groups studying neuropsychiatric disorders to accelerate the pace of research.
| Original language | English |
|---|---|
| Pages (from-to) | 1063-7 |
| Number of pages | 5 |
| Journal | Neuron |
| Volume | 73 |
| Issue number | 6 |
| DOIs | |
| State | Published - 22 Mar 2012 |
Bibliographical note
Copyright © 2012 Elsevier Inc. All rights reserved.Keywords
- Adolescent
- Child
- Child Development Disorders, Pervasive/diagnosis
- Child, Preschool
- Chromosome Deletion
- Chromosomes, Human, Pair 16/genetics
- Developmental Disabilities/diagnosis
- Family Health
- Female
- Genetic Predisposition to Disease/genetics
- Genetic Testing
- Humans
- Infant
- Information Dissemination
- Male
- Neurodegenerative Diseases/diagnosis
- Neuroimaging
- Neurophysiology
- Phenotype
- Retrospective Studies
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