Simple Endoscopic Score of Crohn Disease and Magnetic Resonance Enterography in Children: Report from ImageKids Study

on behalf of the ImageKids study group. NCT01881490

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11 Scopus citations


Objectives: We aimed to explore the ability of magnetic resonance enterography (MRE) to impute the simple endoscopic score of Crohn disease (SES-CD) in children with CD, in whom failure of ileal intubation is common and may impair SES-CD calculation in clinical studies. Methods: This is a substudy of the prospective ImageKids study in which children with CD underwent ileocolonoscopy (scored by SES-CD) and MRE (scored on a 100 mm visual analogue scale [VAS] and by MaRIA). Mucosal healing (MH) was defined as SES-CD <3, MRE-VAS <20 mm, and/or MaRIA <7. Results: A total of 237 children (22 centers, age 11.5 ± 3.3 years), were enrolled. Ileal intubation has failed in 40 of 237 (17%). The agreement between SES-CD and MRE was 75% (k = 0.508, P < 0.001) in the ileum, and 68% to 85% in the colonic segments (k = 0.21-0.50, P < 0.001). The sensitivity and specificity of ileal MRE-VAS for MH were 91.7% (95% confidence interval 0.84-0.96) and 53.1% (95% confidence interval 0.43-0.63), respectively. The ileal MaRIA score (calculated in 33/40) was higher in the children without ileal intubation than in the others (20.5 ± 7.1 vs 15.1 ± 10.8, respectively, P = 0.0018). In 7% (16/237) of children, isolated active ileal disease would have been missed when considering SES-CD only. A multivariable model predicted the ileal SES-CD subscore from the MaRIA: SES-CDileum = 1.145 + 0.169 × MaRIAileum rounded to the nearest whole number (R2 = 0.17). Applying this model to the children without ileal intubation revealed that 29 of 33 (88%) had ileal disease; 8 of 29 patients (28%) with normal colonic SES-CD had imputed ileal SES-CD ≥3. Conclusions: MRE is useful for imputing the ileal disease in pediatric clinical studies, overcoming the problem of ileal nonintubation.

Original languageAmerican English
Pages (from-to)461-465
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Issue number4
StatePublished - 1 Oct 2019

Bibliographical note

Funding Information:
This work has been funded by an educational grant from Abbvie (North Chicago, IL). Abbvie was, however, not involved in any part of the study, including its design, conduct monitoring, analysis, and writing the manuscript.

Publisher Copyright:
Copyright © 2019 ESPGHAN and NASPGHAN. All rights reserved.


  • Crohn disease
  • MaRIA
  • children
  • magnetic resonance enterography
  • simple endoscopic score of Crohn disease


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