Abstract
A simple multisubunit model for a regulatory enzyme is presented. Each subunit consists of an active and a regulatory site. We examine the molecular conditions under which a positive ligand-ligand cooperativity combined with a negative ligand-effector cooperativitiy produces a sharp inverted s-shaped regulatory curve in this system.
Original language | English |
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Pages (from-to) | 14544-14548 |
Number of pages | 5 |
Journal | Journal of Physical Chemistry |
Volume | 99 |
Issue number | 39 |
DOIs | |
State | Published - 1995 |