Simple equilibrium model for allosteric regulatory enzymes

Y. Bohbot, A. Ben-Naim*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A simple multisubunit model for a regulatory enzyme is presented. Each subunit consists of an active and a regulatory site. We examine the molecular conditions under which a positive ligand-ligand cooperativity combined with a negative ligand-effector cooperativitiy produces a sharp inverted s-shaped regulatory curve in this system.

Original languageEnglish
Pages (from-to)14544-14548
Number of pages5
JournalJournal of Physical Chemistry
Volume99
Issue number39
DOIs
StatePublished - 1995

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