Single cell biology—a Keystone Symposia report

Jennifer Cable; Michael B. Elowitz; Ana I. Domingos; Naomi Habib; Shalev Itzkovitz; Homaira Hamidzada; Michael S. Balzer; Itai Yanai; Prisca Liberali; Jessica Whited; Aaron Streets; Long Cai; Andrew B. Stergachis; Clarice Kit Yee Hong; Leeat Keren; Martin Guilliams; Uri Alon; Alex K. Shalek; Regan Hamel; Sarah J. Pfau; Arjun Raj; Stephen R. Quake; Nancy R. Zhang; Jean Fan; Cole Trapnell; Bo Wang; Noah F. Greenwald; Roser Vento-Tormo; Silvia D.M. Santos; Sabrina L. Spencer; Hernan G. Garcia; Geethika Arekatla; Federico Gaiti; Rinat Arbel-Goren; Steffen Rulands; Jan Philipp Junker; Allon M. Klein; Samantha A. Morris; John I. Murray; Kate E. Galloway; Michael Ratz; Merrit Romeike

doi:10.1111/nyas.14692

Single cell biology—a Keystone Symposia report

Jennifer Cable^*, Michael B. Elowitz, Ana I. Domingos, Naomi Habib, Shalev Itzkovitz, Homaira Hamidzada, Michael S. Balzer, Itai Yanai, Prisca Liberali, Jessica Whited, Aaron Streets, Long Cai, Andrew B. Stergachis, Clarice Kit Yee Hong, Leeat Keren, Martin Guilliams, Uri Alon, Alex K. Shalek, Regan Hamel, Sarah J. PfauArjun Raj, Stephen R. Quake, Nancy R. Zhang, Jean Fan, Cole Trapnell, Bo Wang, Noah F. Greenwald, Roser Vento-Tormo, Silvia D.M. Santos, Sabrina L. Spencer, Hernan G. Garcia, Geethika Arekatla, Federico Gaiti, Rinat Arbel-Goren, Steffen Rulands, Jan Philipp Junker, Allon M. Klein, Samantha A. Morris, John I. Murray, Kate E. Galloway, Michael Ratz, Merrit Romeike

^*Corresponding author for this work

Edmond & Lily Safra Center for Brain Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium “Single Cell Biology” to discuss advances both in single cell applications and technologies.

Original language	American English
Pages (from-to)	74-97
Number of pages	24
Journal	Annals of the New York Academy of Sciences
Volume	1506
Issue number	1
DOIs	https://doi.org/10.1111/nyas.14692
State	Published - Dec 2021

Bibliographical note

Funding Information:
M.S. Balzer is supported by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grant BA 6205/2-1. M. Ratz is supported by a DFG Research Fellowship, Grant RA 2889/1-1. J. Fan is supported by the National Science Foundation, Grant No. 2047611.

Publisher Copyright:
© 2021 New York Academy of Sciences.

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Cable, J., Elowitz, M. B., Domingos, A. I., Habib, N., Itzkovitz, S., Hamidzada, H., Balzer, M. S., Yanai, I., Liberali, P., Whited, J., Streets, A., Cai, L., Stergachis, A. B., Hong, C. K. Y., Keren, L., Guilliams, M., Alon, U., Shalek, A. K., Hamel, R., ... Romeike, M. (2021). Single cell biology—a Keystone Symposia report. Annals of the New York Academy of Sciences, 1506(1), 74-97. https://doi.org/10.1111/nyas.14692

@article{dcb9b58ddf26432786da0649e2493b22,

title = "Single cell biology—a Keystone Symposia report",

abstract = "Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium “Single Cell Biology” to discuss advances both in single cell applications and technologies.",

author = "Jennifer Cable and Elowitz, {Michael B.} and Domingos, {Ana I.} and Naomi Habib and Shalev Itzkovitz and Homaira Hamidzada and Balzer, {Michael S.} and Itai Yanai and Prisca Liberali and Jessica Whited and Aaron Streets and Long Cai and Stergachis, {Andrew B.} and Hong, {Clarice Kit Yee} and Leeat Keren and Martin Guilliams and Uri Alon and Shalek, {Alex K.} and Regan Hamel and Pfau, {Sarah J.} and Arjun Raj and Quake, {Stephen R.} and Zhang, {Nancy R.} and Jean Fan and Cole Trapnell and Bo Wang and Greenwald, {Noah F.} and Roser Vento-Tormo and Santos, {Silvia D.M.} and Spencer, {Sabrina L.} and Garcia, {Hernan G.} and Geethika Arekatla and Federico Gaiti and Rinat Arbel-Goren and Steffen Rulands and Junker, {Jan Philipp} and Klein, {Allon M.} and Morris, {Samantha A.} and Murray, {John I.} and Galloway, {Kate E.} and Michael Ratz and Merrit Romeike",

note = "Funding Information: M.S. Balzer is supported by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grant BA 6205/2-1. M. Ratz is supported by a DFG Research Fellowship, Grant RA 2889/1-1. J. Fan is supported by the National Science Foundation, Grant No. 2047611. Publisher Copyright: {\textcopyright} 2021 New York Academy of Sciences.",

year = "2021",

month = dec,

doi = "10.1111/nyas.14692",

language = "American English",

volume = "1506",

pages = "74--97",

journal = "Annals of the New York Academy of Sciences",

issn = "0077-8923",

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Cable, J, Elowitz, MB, Domingos, AI, Habib, N, Itzkovitz, S, Hamidzada, H, Balzer, MS, Yanai, I, Liberali, P, Whited, J, Streets, A, Cai, L, Stergachis, AB, Hong, CKY, Keren, L, Guilliams, M, Alon, U, Shalek, AK, Hamel, R, Pfau, SJ, Raj, A, Quake, SR, Zhang, NR, Fan, J, Trapnell, C, Wang, B, Greenwald, NF, Vento-Tormo, R, Santos, SDM, Spencer, SL, Garcia, HG, Arekatla, G, Gaiti, F, Arbel-Goren, R, Rulands, S, Junker, JP, Klein, AM, Morris, SA, Murray, JI, Galloway, KE, Ratz, M & Romeike, M 2021, 'Single cell biology—a Keystone Symposia report', Annals of the New York Academy of Sciences, vol. 1506, no. 1, pp. 74-97. https://doi.org/10.1111/nyas.14692

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T1 - Single cell biology—a Keystone Symposia report

AU - Cable, Jennifer

AU - Elowitz, Michael B.

AU - Domingos, Ana I.

AU - Habib, Naomi

AU - Itzkovitz, Shalev

AU - Hamidzada, Homaira

AU - Balzer, Michael S.

AU - Yanai, Itai

AU - Liberali, Prisca

AU - Whited, Jessica

AU - Streets, Aaron

AU - Cai, Long

AU - Stergachis, Andrew B.

AU - Hong, Clarice Kit Yee

AU - Keren, Leeat

AU - Guilliams, Martin

AU - Alon, Uri

AU - Shalek, Alex K.

AU - Hamel, Regan

AU - Pfau, Sarah J.

AU - Raj, Arjun

AU - Quake, Stephen R.

AU - Zhang, Nancy R.

AU - Fan, Jean

AU - Trapnell, Cole

AU - Wang, Bo

AU - Greenwald, Noah F.

AU - Vento-Tormo, Roser

AU - Santos, Silvia D.M.

AU - Spencer, Sabrina L.

AU - Garcia, Hernan G.

AU - Arekatla, Geethika

AU - Gaiti, Federico

AU - Arbel-Goren, Rinat

AU - Rulands, Steffen

AU - Junker, Jan Philipp

AU - Klein, Allon M.

AU - Morris, Samantha A.

AU - Murray, John I.

AU - Galloway, Kate E.

AU - Ratz, Michael

AU - Romeike, Merrit

N1 - Funding Information: M.S. Balzer is supported by German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) Grant BA 6205/2-1. M. Ratz is supported by a DFG Research Fellowship, Grant RA 2889/1-1. J. Fan is supported by the National Science Foundation, Grant No. 2047611. Publisher Copyright: © 2021 New York Academy of Sciences.

PY - 2021/12

Y1 - 2021/12

N2 - Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium “Single Cell Biology” to discuss advances both in single cell applications and technologies.

AB - Single cell biology has the potential to elucidate many critical biological processes and diseases, from development and regeneration to cancer. Single cell analyses are uncovering the molecular diversity of cells, revealing a clearer picture of the variation among and between different cell types. New techniques are beginning to unravel how differences in cell state—transcriptional, epigenetic, and other characteristics—can lead to different cell fates among genetically identical cells, which underlies complex processes such as embryonic development, drug resistance, response to injury, and cellular reprogramming. Single cell technologies also pose significant challenges relating to processing and analyzing vast amounts of data collected. To realize the potential of single cell technologies, new computational approaches are needed. On March 17–19, 2021, experts in single cell biology met virtually for the Keystone eSymposium “Single Cell Biology” to discuss advances both in single cell applications and technologies.

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DO - 10.1111/nyas.14692

M3 - Article

C2 - 34605044

AN - SCOPUS:85121734089

SN - 0077-8923

VL - 1506

SP - 74

EP - 97

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

IS - 1

ER -

Single cell biology—a Keystone Symposia report

Abstract

Bibliographical note

UN SDGs

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