Abstract
A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.
Original language | English |
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Pages (from-to) | 6789-6792 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 30 |
DOIs | |
State | Published - 18 Jul 2011 |
Keywords
- gold nanoparticles
- metabolic pathways
- NADH
- plasmon resonance Rayleigh scattering