Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways

Lei Zhang, Yang Li, Da Wei Li, Chao Jing, Xiaoyuan Chen, Min Lv, Qing Huang, Yi Tao Long*, Itamar Willner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

155 Scopus citations

Abstract

A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.

Original languageEnglish
Pages (from-to)6789-6792
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number30
DOIs
StatePublished - 18 Jul 2011

Keywords

  • gold nanoparticles
  • metabolic pathways
  • NADH
  • plasmon resonance Rayleigh scattering

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