Single-molecule DNA detection using a novel SP1 protein nanopore

Hai Yan Wang, Yang Li, Li Xia Qin, Arnon Heyman, Oded Shoseyov, Itamar Willner, Yi Tao Long*, He Tian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.

Original languageAmerican English
Pages (from-to)1741-1743
Number of pages3
JournalChemical Communications
Issue number17
StatePublished - 31 Jan 2013


Dive into the research topics of 'Single-molecule DNA detection using a novel SP1 protein nanopore'. Together they form a unique fingerprint.

Cite this