Single-molecule DNA detection using a novel SP1 protein nanopore

Hai Yan Wang; Yang Li; Li Xia Qin; Arnon Heyman; Oded Shoseyov; Itamar Willner; Yi Tao Long; He Tian

doi:10.1039/c3cc38939a

Single-molecule DNA detection using a novel SP1 protein nanopore

Hai Yan Wang, Yang Li, Li Xia Qin, Arnon Heyman, Oded Shoseyov, Itamar Willner, Yi Tao Long^*, He Tian

^*Corresponding author for this work

Institute of Plant Sciences and Genetics in Agriculture

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

SP1 protein as a new type of biological nanopore is described and is utilized to distinguish single-stranded DNA at the single-molecule level. Using the SP1 nanopore to investigate single molecule detection broadens the existing research areas of pore-forming biomaterials from unsymmetrical biological nanopores to symmetrical biological nanopores. This novel nanopore could provide a good candidate for single-molecule detection and characterization of biomaterial applications.

Original language	English
Pages (from-to)	1741-1743
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	17
DOIs	https://doi.org/10.1039/c3cc38939a
State	Published - 31 Jan 2013

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AU - Willner, Itamar

AU - Long, Yi Tao

AU - Tian, He

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Single-molecule DNA detection using a novel SP1 protein nanopore

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