TY - JOUR
T1 - Single-neuron representation of learned complex sounds in the auditory cortex
AU - Wang, Meng
AU - Liao, Xiang
AU - Li, Ruijie
AU - Liang, Shanshan
AU - Ding, Ran
AU - Li, Jingcheng
AU - Zhang, Jianxiong
AU - He, Wenjing
AU - Liu, Ke
AU - Pan, Junxia
AU - Zhao, Zhikai
AU - Li, Tong
AU - Zhang, Kuan
AU - Li, Xingyi
AU - Lyu, Jing
AU - Zhou, Zhenqiao
AU - Varga, Zsuzsanna
AU - Mi, Yuanyuan
AU - Zhou, Yi
AU - Yan, Junan
AU - Zeng, Shaoqun
AU - Liu, Jian K.
AU - Konnerth, Arthur
AU - Nelken, Israel
AU - Jia, Hongbo
AU - Chen, Xiaowei
N1 - Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - The sensory responses of cortical neuronal populations following training have been extensively studied. However, the spike firing properties of individual cortical neurons following training remain unknown. Here, we have combined two-photon Ca2+ imaging and single-cell electrophysiology in awake behaving mice following auditory associative training. We find a sparse set (~5%) of layer 2/3 neurons in the primary auditory cortex, each of which reliably exhibits high-rate prolonged burst firing responses to the trained sound. Such bursts are largely absent in the auditory cortex of untrained mice. Strikingly, in mice trained with different multitone chords, we discover distinct subsets of neurons that exhibit bursting responses specifically to a chord but neither to any constituent tone nor to the other chord. Thus, our results demonstrate an integrated representation of learned complex sounds in a small subset of cortical neurons.
AB - The sensory responses of cortical neuronal populations following training have been extensively studied. However, the spike firing properties of individual cortical neurons following training remain unknown. Here, we have combined two-photon Ca2+ imaging and single-cell electrophysiology in awake behaving mice following auditory associative training. We find a sparse set (~5%) of layer 2/3 neurons in the primary auditory cortex, each of which reliably exhibits high-rate prolonged burst firing responses to the trained sound. Such bursts are largely absent in the auditory cortex of untrained mice. Strikingly, in mice trained with different multitone chords, we discover distinct subsets of neurons that exhibit bursting responses specifically to a chord but neither to any constituent tone nor to the other chord. Thus, our results demonstrate an integrated representation of learned complex sounds in a small subset of cortical neurons.
UR - http://www.scopus.com/inward/record.url?scp=85089998104&partnerID=8YFLogxK
U2 - 10.1038/s41467-020-18142-z
DO - 10.1038/s41467-020-18142-z
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C2 - 32868773
AN - SCOPUS:85089998104
SN - 2041-1723
VL - 11
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 4361
ER -