Single-step synthesis of salans and substituted salans by Mannich condensation

Edit Y. Tshuva; Natalie Gendeziuk; Moshe Kol

doi:10.1016/S0040-4039(01)01264-3

Single-step synthesis of salans and substituted salans by Mannich condensation

Edit Y. Tshuva, Natalie Gendeziuk, Moshe Kol^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

A convenient route for the synthesis of a variety of salan-type compounds is introduced. The synthesis is based on a single-step Mannich condensation between readily available starting materials: primary or secondary amines, formaldehyde and substituted phenols. This methodology is suitable for the preparation of chiral salans as well, which may find applications in asymmetric catalysis.

Original language	English
Pages (from-to)	6405-6407
Number of pages	3
Journal	Tetrahedron Letters
Volume	42
Issue number	36
DOIs	https://doi.org/10.1016/S0040-4039(01)01264-3
State	Published - 3 Sep 2001
Externally published	Yes

Keywords

Chiral compounds
Mannich condensation
Salans
Substituted salans

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10.1016/S0040-4039(01)01264-3

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abstract = "A convenient route for the synthesis of a variety of salan-type compounds is introduced. The synthesis is based on a single-step Mannich condensation between readily available starting materials: primary or secondary amines, formaldehyde and substituted phenols. This methodology is suitable for the preparation of chiral salans as well, which may find applications in asymmetric catalysis.",

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AU - Tshuva, Edit Y.

AU - Gendeziuk, Natalie

AU - Kol, Moshe

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Y1 - 2001/9/3

N2 - A convenient route for the synthesis of a variety of salan-type compounds is introduced. The synthesis is based on a single-step Mannich condensation between readily available starting materials: primary or secondary amines, formaldehyde and substituted phenols. This methodology is suitable for the preparation of chiral salans as well, which may find applications in asymmetric catalysis.

AB - A convenient route for the synthesis of a variety of salan-type compounds is introduced. The synthesis is based on a single-step Mannich condensation between readily available starting materials: primary or secondary amines, formaldehyde and substituted phenols. This methodology is suitable for the preparation of chiral salans as well, which may find applications in asymmetric catalysis.

KW - Chiral compounds

KW - Mannich condensation

KW - Salans

KW - Substituted salans

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JO - Tetrahedron Letters

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Single-step synthesis of salans and substituted salans by Mannich condensation

Abstract

Keywords

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