Single-step synthesis of salans and substituted salans by Mannich condensation

Edit Y. Tshuva, Natalie Gendeziuk, Moshe Kol*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


A convenient route for the synthesis of a variety of salan-type compounds is introduced. The synthesis is based on a single-step Mannich condensation between readily available starting materials: primary or secondary amines, formaldehyde and substituted phenols. This methodology is suitable for the preparation of chiral salans as well, which may find applications in asymmetric catalysis.

Original languageAmerican English
Pages (from-to)6405-6407
Number of pages3
JournalTetrahedron Letters
Issue number36
StatePublished - 3 Sep 2001
Externally publishedYes


  • Chiral compounds
  • Mannich condensation
  • Salans
  • Substituted salans


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