SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

Keyphrases

• Growth Hormone Receptor 100%
• Insulin-like 100%
• Sirtuin 1 (SIRT1) 100%
• Protein Tyrosine Phosphatase 1B (PTP1B) 100%
• Osteoarthritis Chondrocyte 100%
• Apoptosis 45%
• Small Interfering RNA (siRNA) 36%
• Chondrocytes 27%
• Cartilage 27%
• Osteoarthritis 27%
• Human Chondrocytes 18%
• Chondrocyte Survival 18%
• Flow Cytometry 9%
• Distinct Mechanism 9%
• Protein Expression 9%
• Knee Osteoarthritis 9%
• Tumor Necrosis Factor-α 9%
• Cell Systems 9%
• Mammalian Target of Rapamycin (mTOR) 9%
• Phosphoinositide 3-kinase (PI3K) 9%
• Immunohistochemical Analysis 9%
• Murine Double Minute 2 (MDM2) 9%
• Anti-apoptotic Proteins 9%
• Protein Kinase 9%
• Chondrocyte Apoptosis 9%
• Immunoblotting 9%
• Protein Deacetylase 9%
• Receptor Phosphorylation 9%
• Expression Plasmid 9%
• Actinomycin D 9%
• Chondrocyte Senescence 9%
• Healthy Knee 9%
• Knee Cartilage 9%

Biochemistry, Genetics and Molecular Biology

• Growth Factor Receptor 100%
• Chondrocyte 100%
• Protein Tyrosine Phosphatase 100%
• Insulin-Like Growth Factor 100%
• Small Interfering RNA 40%
• Downregulation 20%
• Plasmid 10%
• P53 10%
• Mediator 10%
• Phosphoinositide 3-Kinase 10%
• Mammalian Target of Rapamycin 10%
• Tumor Necrosis Factor 10%
• Protein Kinase B 10%
• Protein Deacetylase 10%
• Dactinomycin 10%
• Immunoblotting 10%
• Flow Cytometry 10%

Pharmacology, Toxicology and Pharmaceutical Science

• Protein Tyrosine Phosphatase 1B 100%
• Somatomedin Receptor 100%
• Small Interfering RNA 44%
• Tumor Necrosis Factor 11%
• Protein P53 11%
• Flow Cytometry 11%
• Western Blot 11%
• Phosphatidylinositol 3 Kinase 11%
• Protein Kinase B 11%
• Dactinomycin 11%