Sirtuin regulation in calorie restriction

Xiaolei Qiu, Katharine V. Brown, Yehu Moran, Danica Chen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

47 Scopus citations


The beneficial effects of calorie restriction diet in extending lifespan and preventing diseases have long been recognized. Recent genetic and molecular studies in model organisms began to uncover the molecular regulation of calorie restriction response, with the gene SIR2 playing an essential role. This article summarizes the latest development on how mammalian SIR2 homologs coordinately regulate the calorie restriction response.

Original languageAmerican English
Pages (from-to)1576-1583
Number of pages8
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Issue number8
StatePublished - Aug 2010
Externally publishedYes

Bibliographical note

Funding Information:
We thank Y. Liu and S. Chiao for comments and acknowledge funding support from the Searle Scholars Program to D.C.


  • Aging
  • Calorie restriction
  • Sirtuin


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