The beneficial effects of calorie restriction diet in extending lifespan and preventing diseases have long been recognized. Recent genetic and molecular studies in model organisms began to uncover the molecular regulation of calorie restriction response, with the gene SIR2 playing an essential role. This article summarizes the latest development on how mammalian SIR2 homologs coordinately regulate the calorie restriction response.
|Number of pages
|Biochimica et Biophysica Acta - Proteins and Proteomics
|Published - Aug 2010
Bibliographical noteFunding Information:
We thank Y. Liu and S. Chiao for comments and acknowledge funding support from the Searle Scholars Program to D.C.
- Calorie restriction