Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Michael Brandwein; Garold Fuks; Avigail Israel; Fareed Sabbah; Emmilia Hodak; Amir Szitenberg; Marco Harari; Droron Steinberg; Zvi Bentwich; Noam Shental; Shiri Meshner

doi:10.1111/php.13119

Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

Michael Brandwein, Garold Fuks, Avigail Israel, Fareed Sabbah, Emmilia Hodak, Amir Szitenberg, Marco Harari, Droron Steinberg, Zvi Bentwich, Noam Shental, Shiri Meshner^*

^*Corresponding author for this work

Institute of Biomedical Research at the Faculty of Dental Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Dead Sea climatotherapy (DSC) is a well-established therapeutic modality for the treatment of several diseases, including atopic dermatitis. Skin microbiome studies have shown that skin microbiome diversity is anticorrelated with both atopic dermatitis severity and concurrent Staphylococcus aureus overgrowth. This study aimed to determine whether DSC induces skin microbiome changes concurrent with clinical improvements in atopic dermatitis. We sampled 35 atopic dermatitis patients and ten healthy controls on both the antecubital and popliteal fossa. High-resolution microbial community profiling was attained by sequencing multiple regions of the 16S rRNA gene. Dysbiosis was observed in both lesional and nonlesional sites, which was partially attenuated following treatment. Severe AD skin underwent the most significant community shifts, and Staphylococcus epidermidis, Streptococcus mitis and Micrococcus luteus relative abundance were significantly affected by Dead Sea climatotherapy. Our study highlights the temporal shifts of the AD skin microbiome induced by Dead Sea climatotherapy and offers potential explanations for the success of climatotherapy on a variety of skin diseases, including AD.

Original language	American English
Pages (from-to)	1446-1453
Number of pages	8
Journal	Photochemistry and Photobiology
Volume	95
Issue number	6
DOIs	https://doi.org/10.1111/php.13119
State	Published - 1 Nov 2019

Bibliographical note

Funding Information:
This study was supported by the Israeli Ministry of Science and Technology (Grant 3-11174). Michael Brandwein is a recipient of the Kaete Klausner Fellowship. The funding organizations were not involved in study design, data collection, data analysis or any other stage of the research. We would like to thank the volunteers that participated in this study. Additionally, we acknowledge Shira Wax and Ira Mezin for assisting in ethical approval and planning. Thank you to Dr. Idit Shiff and Dr. Abed Nasereddin of the Hebrew University of Jerusalem Genomic Applications Laboratory, Core Research Facility, Faculty of Medicine, for providing sequencing support.

Publisher Copyright:
© 2019 American Society for Photobiology

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title = "Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy",

abstract = "Dead Sea climatotherapy (DSC) is a well-established therapeutic modality for the treatment of several diseases, including atopic dermatitis. Skin microbiome studies have shown that skin microbiome diversity is anticorrelated with both atopic dermatitis severity and concurrent Staphylococcus aureus overgrowth. This study aimed to determine whether DSC induces skin microbiome changes concurrent with clinical improvements in atopic dermatitis. We sampled 35 atopic dermatitis patients and ten healthy controls on both the antecubital and popliteal fossa. High-resolution microbial community profiling was attained by sequencing multiple regions of the 16S rRNA gene. Dysbiosis was observed in both lesional and nonlesional sites, which was partially attenuated following treatment. Severe AD skin underwent the most significant community shifts, and Staphylococcus epidermidis, Streptococcus mitis and Micrococcus luteus relative abundance were significantly affected by Dead Sea climatotherapy. Our study highlights the temporal shifts of the AD skin microbiome induced by Dead Sea climatotherapy and offers potential explanations for the success of climatotherapy on a variety of skin diseases, including AD.",

author = "Michael Brandwein and Garold Fuks and Avigail Israel and Fareed Sabbah and Emmilia Hodak and Amir Szitenberg and Marco Harari and Droron Steinberg and Zvi Bentwich and Noam Shental and Shiri Meshner",

note = "Funding Information: This study was supported by the Israeli Ministry of Science and Technology (Grant 3-11174). Michael Brandwein is a recipient of the Kaete Klausner Fellowship. The funding organizations were not involved in study design, data collection, data analysis or any other stage of the research. We would like to thank the volunteers that participated in this study. Additionally, we acknowledge Shira Wax and Ira Mezin for assisting in ethical approval and planning. Thank you to Dr. Idit Shiff and Dr. Abed Nasereddin of the Hebrew University of Jerusalem Genomic Applications Laboratory, Core Research Facility, Faculty of Medicine, for providing sequencing support. Publisher Copyright: {\textcopyright} 2019 American Society for Photobiology",

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N2 - Dead Sea climatotherapy (DSC) is a well-established therapeutic modality for the treatment of several diseases, including atopic dermatitis. Skin microbiome studies have shown that skin microbiome diversity is anticorrelated with both atopic dermatitis severity and concurrent Staphylococcus aureus overgrowth. This study aimed to determine whether DSC induces skin microbiome changes concurrent with clinical improvements in atopic dermatitis. We sampled 35 atopic dermatitis patients and ten healthy controls on both the antecubital and popliteal fossa. High-resolution microbial community profiling was attained by sequencing multiple regions of the 16S rRNA gene. Dysbiosis was observed in both lesional and nonlesional sites, which was partially attenuated following treatment. Severe AD skin underwent the most significant community shifts, and Staphylococcus epidermidis, Streptococcus mitis and Micrococcus luteus relative abundance were significantly affected by Dead Sea climatotherapy. Our study highlights the temporal shifts of the AD skin microbiome induced by Dead Sea climatotherapy and offers potential explanations for the success of climatotherapy on a variety of skin diseases, including AD.

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Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy

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