Sleep in Sickle Cell Disease

Alex Gileles-Hillel

doi:10.1007/978-3-030-65574-7_48

Sleep in Sickle Cell Disease

Alex Gileles-Hillel^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Sickle cell disease is a common hereditary blood disorder characterized by endothelial dysfunction, tissue ischemia, and systemic inflammation, with significant morbidity and increased mortality. Only recently had the sleep disturbances in general, and sleep-disordered breathing in particular, received attention as potential contributors to sickle cell disease manifestations and clinical outcomes. In this chapter, we will critically review in detail the potential epidemiological links between SCD and sleep disorders, focusing on the SDB, and explore the overlapping pathophysiological considerations and their potential impact on clinical phenotype and course.

Original language	English
Title of host publication	Pediatric Sleep Medicine
Subtitle of host publication	Mechanisms and Comprehensive Guide to Clinical Evaluation and Management
Publisher	Springer Science+Business Media
Pages	581-593
Number of pages	13
ISBN (Electronic)	9783030655747
ISBN (Print)	9783030655730
DOIs	https://doi.org/10.1007/978-3-030-65574-7_48
State	Published - 1 Jan 2021

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2021

Keywords

Acute chest syndrome
Chronic pain
Hypoxemia
Sickle cell disease
Sleep
Sleep apnea
Sleep-disordered breathing

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10.1007/978-3-030-65574-7_48

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KW - Chronic pain

KW - Hypoxemia

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KW - Sleep apnea

KW - Sleep-disordered breathing

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Sleep in Sickle Cell Disease

Abstract

Bibliographical note

Keywords

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