Sleeve gastrectomy is associated with a greater reduction in plasma liver enzymes than bypass surgeries—a registry-based two-year follow-up analysis

Shira Azulai, Ronit Grinbaum, Nahum Beglaibter, Shai Meron Eldar, Moshe Rubin, Rachel Ben Haroush Schyr, Orly Romano-Zelekha, Danny Ben-Zvi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) on the levels of ALT by analysis of two-year follow-up data from 4980 patients in the Israeli Bariatric Registry that included laboratory tests and demographic information. Pre-oper-ative characteristics of patients, and particularly levels of liver enzymes, were similar across surgery types. Regression modeling and retrospective matching showed that SG was superior to RYGB and OAGB in reducing ALT levels, and in reducing the fraction of patients with abnormally high ALT levels. Two-year post-surgery, an increase in ALT levels from normal to abnormal levels was ob-served in 5% of SG patients, and in 18% and 23% of RYGB and OAGB patients. In conclusion, SG leads to a greater reduction in ALT levels compared with bypass surgeries and a lower incidence of post-surgical elevation of ALT levels. Further studies are required to identify the cause for the rise in liver enzymes, and to determine whether ALT levels correlate with liver pathology especially following bariatric surgery.

Original languageAmerican English
Article number1144
Pages (from-to)1-10
Number of pages10
JournalJournal of Clinical Medicine
Volume10
Issue number5
DOIs
StatePublished - 9 Mar 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • ALT
  • Bariatric surgery
  • Logistic model
  • Weight-loss

Fingerprint

Dive into the research topics of 'Sleeve gastrectomy is associated with a greater reduction in plasma liver enzymes than bypass surgeries—a registry-based two-year follow-up analysis'. Together they form a unique fingerprint.

Cite this