Slip slidin' away of mitosis with CRL2Zyg11

Michael Brandeis

doi:10.1083/jcb.201609086

Slip slidin' away of mitosis with CRL2Zyg11

Michael Brandeis^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphasepromoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201601083) show that the E3 ligase CRL2^ZYG11 degrades cyclin B1, allowing mitotic slippage.

Original language	English
Pages (from-to)	143-145
Number of pages	3
Journal	Journal of Cell Biology
Volume	215
Issue number	2
DOIs	https://doi.org/10.1083/jcb.201609086
State	Published - 2016

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Publisher Copyright:
© 2016 Brandeis.

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abstract = "The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphasepromoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.",

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AB - The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphasepromoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. http ://dx .doi .org /10 .1083 /jcb .201601083) show that the E3 ligase CRL2ZYG11 degrades cyclin B1, allowing mitotic slippage.

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Slip slidin' away of mitosis with CRL2Zyg11

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