Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport

Yafeng Wu, Dianyu Wang, Itamar Willner*, Ye Tian, Lei Jiang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

106 Scopus citations

Abstract

Nanochannels based on smart DNA hydrogels as stimulus-responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three-dimensional networks with space negative charges, the ion flux and rectification ratio are significantly enhanced. Upon cyclic treatment with K+ ions and crown ether, the DNA hydrogel states could be reversibly switched between less stiff and stiff networks, providing the gating mechanism of the nanochannel. Based on the architecture of DNA hydrogels and pH stimulus, cation or anion transport direction could be precisely controlled and multiple gating features are achieved. Meanwhile, G-quadruplex DNA in the hydrogels might be replaced by other stimulus-responsive DNA molecules, peptides, or proteins, and thus this work opens a new route for improving the functionalities of nanochannel by intelligent hydrogels.

Original languageEnglish
Pages (from-to)7790-7794
Number of pages5
JournalAngewandte Chemie - International Edition
Volume57
Issue number26
DOIs
StatePublished - 25 Jun 2018

Bibliographical note

Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Keywords

  • adjustable selective ion transport
  • DNA hydrogels
  • high ion flux
  • ion channels

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