TY - JOUR
T1 - Smart DNA Hydrogel Integrated Nanochannels with High Ion Flux and Adjustable Selective Ionic Transport
AU - Wu, Yafeng
AU - Wang, Dianyu
AU - Willner, Itamar
AU - Tian, Ye
AU - Jiang, Lei
N1 - Publisher Copyright:
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2018/6/25
Y1 - 2018/6/25
N2 - Nanochannels based on smart DNA hydrogels as stimulus-responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three-dimensional networks with space negative charges, the ion flux and rectification ratio are significantly enhanced. Upon cyclic treatment with K+ ions and crown ether, the DNA hydrogel states could be reversibly switched between less stiff and stiff networks, providing the gating mechanism of the nanochannel. Based on the architecture of DNA hydrogels and pH stimulus, cation or anion transport direction could be precisely controlled and multiple gating features are achieved. Meanwhile, G-quadruplex DNA in the hydrogels might be replaced by other stimulus-responsive DNA molecules, peptides, or proteins, and thus this work opens a new route for improving the functionalities of nanochannel by intelligent hydrogels.
AB - Nanochannels based on smart DNA hydrogels as stimulus-responsive architecture are presented for the first time. In contrast to other responsive molecules existing in the nanochannel in monolayer configurations, the DNA hydrogels are three-dimensional networks with space negative charges, the ion flux and rectification ratio are significantly enhanced. Upon cyclic treatment with K+ ions and crown ether, the DNA hydrogel states could be reversibly switched between less stiff and stiff networks, providing the gating mechanism of the nanochannel. Based on the architecture of DNA hydrogels and pH stimulus, cation or anion transport direction could be precisely controlled and multiple gating features are achieved. Meanwhile, G-quadruplex DNA in the hydrogels might be replaced by other stimulus-responsive DNA molecules, peptides, or proteins, and thus this work opens a new route for improving the functionalities of nanochannel by intelligent hydrogels.
KW - adjustable selective ion transport
KW - DNA hydrogels
KW - high ion flux
KW - ion channels
UR - http://www.scopus.com/inward/record.url?scp=85048798289&partnerID=8YFLogxK
U2 - 10.1002/anie.201803222
DO - 10.1002/anie.201803222
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C2 - 29687555
AN - SCOPUS:85048798289
SN - 1433-7851
VL - 57
SP - 7790
EP - 7794
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 26
ER -