Sochetanie geterozigotnogo nositel'stva leidenskoi mutatsii faktora svertyvaniia krovi s éritrotsitozom kak prichina tromboza glubokikh ven bedra.

L. I. Idelson; I. I. Albert; B. Rudensky; E. Levy-Lahad; P. Renbaum; G. Klein

Sochetanie geterozigotnogo nositel'stva leidenskoi mutatsii faktora svertyvaniia krovi s éritrotsitozom kak prichina tromboza glubokikh ven bedra.

Translated title of the contribution: Combination of heterozygote blood coagulation factor V Leiden carriage with erythrocytosis as a cause of the hip deep vein thrombosis

L. I. Idelson^*
, I. I. Albert
, B. Rudensky
, E. Levy-Lahad
, P. Renbaum
, G. Klein

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

Abstract

AIM: To reject one of the variants of inherited thrombophylia in a 64-year-old patient with deep thrombosis of leg veins and high hemoglobin and red cell levels. MATERIAL AND METHODS: The study was made of antithrombin III and protein C, protein S levels; resistance to activated protein C; molecular structure of DNA coding factor 5; methylenetetrahydrofolate reductase. RESULTS: The patient was diagnosed to have heterozygote factor V Leiden mutation. The replacement of arginine by glutamine in position 506 of factor V molecule raises the risk of thrombosis. This risk was aggravated by high hemoglobin, red cells, hematocrit, low volume of circulating plasma, smoking. The patient had normal levels of leukocytes and platelets, normal spleen size, slightly lowered level of erythropoietin. CONCLUSION: The presence of thrombosis in patients with erythremia or erythrocytosis rejects one of the thrombophilia forms.

Translated title of the contribution	Combination of heterozygote blood coagulation factor V Leiden carriage with erythrocytosis as a cause of the hip deep vein thrombosis
Original language	Russian
Pages (from-to)	66-70
Number of pages	5
Journal	Terapevticheskii Arkhiv
Volume	74
Issue number	2
State	Published - 2002

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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@article{222dc535a482498bb0677c2de53aab43,

title = "Sochetanie geterozigotnogo nositel'stva leidenskoi mutatsii faktora svertyvaniia krovi s {\'e}ritrotsitozom kak prichina tromboza glubokikh ven bedra.",

abstract = "AIM: To reject one of the variants of inherited thrombophylia in a 64-year-old patient with deep thrombosis of leg veins and high hemoglobin and red cell levels. MATERIAL AND METHODS: The study was made of antithrombin III and protein C, protein S levels; resistance to activated protein C; molecular structure of DNA coding factor 5; methylenetetrahydrofolate reductase. RESULTS: The patient was diagnosed to have heterozygote factor V Leiden mutation. The replacement of arginine by glutamine in position 506 of factor V molecule raises the risk of thrombosis. This risk was aggravated by high hemoglobin, red cells, hematocrit, low volume of circulating plasma, smoking. The patient had normal levels of leukocytes and platelets, normal spleen size, slightly lowered level of erythropoietin. CONCLUSION: The presence of thrombosis in patients with erythremia or erythrocytosis rejects one of the thrombophilia forms.",

author = "Idelson, \{L. I.\} and Albert, \{I. I.\} and B. Rudensky and E. Levy-Lahad and P. Renbaum and G. Klein",

year = "2002",

language = "רוסית",

volume = "74",

pages = "66--70",

journal = "Terapevticheskii Arkhiv",

issn = "0040-3660",

publisher = "Consilium MediCum",

number = "2",

}

TY - JOUR

T1 - Sochetanie geterozigotnogo nositel'stva leidenskoi mutatsii faktora svertyvaniia krovi s éritrotsitozom kak prichina tromboza glubokikh ven bedra.

AU - Idelson, L. I.

AU - Albert, I. I.

AU - Rudensky, B.

AU - Levy-Lahad, E.

AU - Renbaum, P.

AU - Klein, G.

PY - 2002

Y1 - 2002

N2 - AIM: To reject one of the variants of inherited thrombophylia in a 64-year-old patient with deep thrombosis of leg veins and high hemoglobin and red cell levels. MATERIAL AND METHODS: The study was made of antithrombin III and protein C, protein S levels; resistance to activated protein C; molecular structure of DNA coding factor 5; methylenetetrahydrofolate reductase. RESULTS: The patient was diagnosed to have heterozygote factor V Leiden mutation. The replacement of arginine by glutamine in position 506 of factor V molecule raises the risk of thrombosis. This risk was aggravated by high hemoglobin, red cells, hematocrit, low volume of circulating plasma, smoking. The patient had normal levels of leukocytes and platelets, normal spleen size, slightly lowered level of erythropoietin. CONCLUSION: The presence of thrombosis in patients with erythremia or erythrocytosis rejects one of the thrombophilia forms.

AB - AIM: To reject one of the variants of inherited thrombophylia in a 64-year-old patient with deep thrombosis of leg veins and high hemoglobin and red cell levels. MATERIAL AND METHODS: The study was made of antithrombin III and protein C, protein S levels; resistance to activated protein C; molecular structure of DNA coding factor 5; methylenetetrahydrofolate reductase. RESULTS: The patient was diagnosed to have heterozygote factor V Leiden mutation. The replacement of arginine by glutamine in position 506 of factor V molecule raises the risk of thrombosis. This risk was aggravated by high hemoglobin, red cells, hematocrit, low volume of circulating plasma, smoking. The patient had normal levels of leukocytes and platelets, normal spleen size, slightly lowered level of erythropoietin. CONCLUSION: The presence of thrombosis in patients with erythremia or erythrocytosis rejects one of the thrombophilia forms.

UR - https://www.scopus.com/pages/publications/0036366352

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C2 - 11899832

AN - SCOPUS:0036366352

SN - 0040-3660

VL - 74

SP - 66

EP - 70

JO - Terapevticheskii Arkhiv

JF - Terapevticheskii Arkhiv

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Sochetanie geterozigotnogo nositel'stva leidenskoi mutatsii faktora svertyvaniia krovi s éritrotsitozom kak prichina tromboza glubokikh ven bedra.

Abstract

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